不同剂量艾司奥美拉唑在急性中-重度非静脉曲张性上消化道出血治疗中的作用

Effect of Different Doses of Esmeprazole in Treatment of Acute Moderate to Severe Non Varicose Upper Gastrointestinal Bleeding

目的探讨对急性中-重度非静脉曲张性上消化道出血患者应用不同剂量艾司奥美拉唑的治疗效果。方法抽取2018年6月-2020年8月成都市龙泉驿区柏合镇公立卫生院70例急性中-重度非静脉曲张性上消化道出血患者,依据艾司奥美拉唑用药剂量分成2组,观察组为大剂量艾司奥美拉唑治疗,对照组采用小剂量艾司奥美拉唑治疗,对比2组的临床数据,包括治疗总有效率、出血控制时间、血压稳定时间、腹痛缓解时间、血清炎症因子水平变化以及药物不良反应率等。结果观察组治疗总有效率优于对照组(P<0.05);观察组的出血控制时间以及完全止血时间均短于对照组(P<0.05);观察组药物不良反应率为低于对照组(P>0.05);观察组的血压稳定时间以及腹痛缓解时间均短于对照组(P<0.05);治疗前2组血清hs-CRP、TNF-α水平对比(P>0.05),治疗后血清hs-CRP、TNF-α水平观察组低于对照组(P<0.05)。结论对于急性中-重度非静脉曲张性上消化道出血患者给予大剂量艾司奥美拉唑可提升临床疗效。

Objective To investigate curative effect of different doses of esomeprazole for patients with acute moderate to severe non varicose upper gastrointestinal bleeding.Methods The paper chose 70 patients with acute moderate to severe non varicose upper gastrointestinal bleeding in our hospital from June 2018 to August 2020,and divided them into two groups according to dosage of esomeprazole.Observation group was treated with high-dose esomeprazole and control group with low-dose esomeprazole.Clinical data between two groups was compared,including total effective rate of treatment,bleeding control time,blood pressure stabilization time,abdominal pain relief time,changes of serum inflammatory factors and incidence of adverse drug reactions.Results Total effective rate of observation group was better than control group(P<0.05);bleeding control time and complete hemostasis time in observation group was shorter than control group(P<0.05);adverse drug reaction incidence of observation group was lower than control group(P>0.05);blood pressure stabilization time and abdominal pain relief time in observation group was shorter than control group(P<0.05);serum hs-CRP and TNF-αlevel comparison of two groups before treatment showed P>0.05,serum hs CRP and TNF-αlevel after treatment in observation group was lower than control group(P<0.05).Conclusion High-dose esmeprazole can improve clinical effect of patients with acute moderate to severe non varicose upper gastrointestinal bleeding.