分析血液灌注联合血液透析对慢性肾脏病患者炎症状态、矿物质、骨代谢及肾功能的临床效果

Clinical Effect Analysis of Hemoperfusion Combined With Hemodialysis on Inflammatory State,Minerals,Bone Metabolism and Renal Function of Patients With Chronic Kidney Disease

目的 分析血液灌注联合血液透析对慢性肾脏病患者炎症状态、矿物质、骨代谢及肾功能的临床效果。方法 选取2018年1月-2020年7月在济南市第七人民医院就诊的52例慢性肾脏疾病患者,根据患者意愿划入研究组与参照组各26例。参照组施以血液透析治疗,研究组血液灌注联合血液透析治疗,比较患者的肾功能改善情况及并不良反应发生情况。结果 研究组TNF-α水平为(373.21±57.16)ng/L、IL-6水平为(176.31±32.44)ng/L,参照组TNF-α水平为(460.52±68.03)ng/L、IL-6水平为(267.81±47.73)ng/L,研究组炎症因子要优于参照组(P<0.05)。治疗后研究组患者的骨密度T值、血钙、血磷指标分别是(2.59±0.22)mmol/L、(0.75±0.19)mmol/L、(-2.03±0.94),参照组患者的骨密度T值、血钙、血磷指标分别是(2.37±0.24)mmol/L、(1.35±0.45)mmol/L、(-1.56±0.73),研究组骨密度、矿物质情况均优于参照组,两组指标比较有统计学意义(P<0.05)。治疗后研究组患者的SCr指标为(98.95±7.16)μmol/L、BUN指标为(6.28±2.44)mmol/L;参照组患者的SCr指标为(110.52±8.06)μmol/L、BUN指标为(7.81±2.71)mmol/L,研究组患者肾功能指标要明显低于参照组患者,数据对比有统计学意义(P<0.05)。治疗期间研究组出现4例不良反应,参照组出现5例不良反应,无统计学意义(P>0.05)。结论 血液灌注联合血液透析治疗可有效控制慢性肾脏病患者的炎症状态,改善患者的骨密度及肾功能指标,建议临床推广。

Objective To analyze clinical effect of hemoperfusion combined with hemodialysis on inflammatory state,minerals,bone metabolism and renal function of patients with chronic kidney disease.Methods The paper chose 52 patients with chronic kidney disease in our hospital from January 2018 to July 2020,and divided them into study group and reference group according to wishes of patients,with 26 cases in each group.Reference group was treated with hemodialysis,and study group with hemoperfusion combined with hemodialysis.Improvement of renal function and incidence of adverse reactions was compared.Results TNF-α level in study group was (373.21±57.16) ng/L,and IL-6 level was (176.31±32.44) ng/L,TNF-α level in reference group was (460.52±68.03) ng/L,and IL-6 level was (267.81±47.73) ng/L respectively.Inflammatory factors in study group were better than reference group (P<0.05).After treatment,T value of bone mineral density,blood calcium and blood phosphorus in study group were (2.59±0.22) mmol/L,(0.75±0.19) mmol/L and (-2.03±0.94) respectively.T value of bone mineral density,blood calcium and blood phosphorus in reference group were (2.37±0.24) mmol/L,(1.35±0.45) mmol/L and (-1.56±0.73) respectively.Bone mineral density and minerals in study group was better than reference group,comparison between two groups was statistically significant,(P<0.05).After treatment,SCr index of study group was (98.95±7.16) μMol/L and BUN was (6.28±2.44) mmol/L;SCr index of reference group was (110.52±8.06) μMol/L and BUN was (7.81±2.71) mmol/L.Indexes of renal function in study group were significantly lower than reference group,comparison between two groups was statistically significant,(P<0.05).During treatment,there were 4 adverse reactions in study group and 5 adverse reactions in reference group,which was not statistically significant (P>0.05).Conclusion Hemoperfusion combined with hemodialysis can control inflammatory state,improve bone mineral density and renal function indexes of patients with chronic kidney disease effectively,which is suggested to be promotion in clinical practice.