头孢哌酮舒巴坦联合雾化吸入治疗慢性阻塞性肺疾病疗效观察及对患者肺功能、相关炎性介质表达的影响

Effect of Cefoperazone Sulbactam Combined With Atomization Inhalation on Chronic Obstructive Pulmonary Disease and Pulmonary Function and Expression of Related Inflammatory Mediators

目的 探讨头孢哌酮舒巴坦联合雾化吸入治疗慢性阻塞性肺疾病(COPD)疗效观察及对患者肺功能、相关炎性介质表达的影响。方法 选择2019年8月-2020年4月于广东省惠州市惠阳三和医院就诊的COPD患者104例,随机分为实验组(n=52)与对照组(n=52),对照组予以基础治疗,实验组基于此加用头孢哌酮舒巴坦联合雾化吸入治疗,比较两组治疗效果。结果 实验组患者治疗后的FEV;、FVC、PEF、FEV;/FVC显著高于对照组,血清CER、α1-AG、α1-AT水平显著低于对照组(P<0.05)。实验组患者的痊愈率、总有效率均显著高于对照组(P<0.05)。结论 头孢哌酮舒巴坦联合雾化吸入治疗可促进COPD患者症状减轻,下调炎症因子表达水平,明显改善其肺功能,有利于病情转归。

Objective To investigate effect of cefoperazone sulbactam combined with atomization inhalation in treatment of chronic obstructive pulmonary disease (COPD) and effect on pulmonary function and expression of related inflammatory mediators.Methods The paper chose 104 cases COPD patients treated in our hospital from August 2019 to April 2020,and divided them into experimental group (n=52) and control group (n=52) randomly.Control group was treated with basic treatment,and experimental group with cefoperazone sulbactam combined with atomization inhalation on the basis.Curative effect between two groups was compared.Results FEV;,FVC,PEF and FEV;/FVC in experimental group were significantly higher than control group,serum CER,α1-AG、 α1-AT level was significantly lower than control group,(P<0.05).Cure rate and total effective rate of experimental group was significantly higher than control group,(P<0.05).Conclusion Cefoperazone sulbactam combined with atomization inhalation can reduce symptoms of COPD patients,reduce expression level of inflammatory factors,improve lung function significantly,which is conducive to prognosis of the disease.