2-溴-6-甲基吡啶甲酸甲酯的合成工艺研究

Study on Synthesis Technology of Methyl 2-Bromo-6-methylpicolinate

2-溴-6-甲基吡啶甲酸甲酯是一种重要的医药、农药中间体,在抗癌和抗炎方面都有重要用途。对2-溴-6-甲基吡啶甲酸甲酯的合成工艺进行了研究,以3-氰基-6-甲基-2(1H)-吡啶酮为起始原料,经过溴代、水解、酯化三步反应得到目标化合物,其结构经^(1)H-NMR和MS表征。该合成路线具有原料成本低廉易得、反应条件较温和、后处理简单、收率高等优点,总收率达87.60%,适合工业化生产。

The title compound is an important pharmaceutical and pesticide intermediate,It has important uses in anti-cancer and anti-inflammatory.The synthesis process of the title compound was improved.The target compound was synthesized by bromination,hydrolysis and esterification reaction with 2-hydroxy-6-methylnicotinonitrile as raw material.The structure of the target compound was characterized by 1H-NMR and MS.The synthetic route has not been reported.The raw materials were cheap and easy to get in this method.The yield was higher in each step with mild reaction conditions and convenient post-processing,which is suitable for industrial production.The total yield was 87.60%.