CK2α'在肝细胞癌组织中的表达及其对预后的影响

Expression and Prognostic Value of CK2α’ in Hepatocellular Carcinoma

目的探究CK2α'在肝细胞癌(HCC)组织中的表达及其对肝癌患者预后的影响。方法收集83例肝癌患者肿瘤组织及癌旁正常组织并制成组织芯片,免疫组织化学法对芯片染色后进行半定量分析,比较CK2α'在肿瘤组织与癌旁组织中的表达差异。χ^(2)检验分析CK2α'的表达与患者临床病理特征的关系。Kaplan-Meier方法分析CK2α'与肝癌预后的关系。结果CK2α'在83例肝癌组织及癌旁正常组织中的平均阳性表达率分别为47.8%及65.4%,CK2α'在肝癌组织中的阳性表达率低于癌旁正常组织且差异有统计学意义(P<0.01);53(74.7%)例肝癌患者癌组织中CK2α'的表达水平显著低于癌旁正常组织;且CK2α'低表达的患者复发率更高、总体生存期更短(P<0.05)。进一步分析发现CK2α'的表达水平与CK19相关(P<0.05)。结论CK2α'在肝癌组织中表达下调且与患者的预后有关,提示CK2α'可能作为肝癌患者预后判断的生物标志物。

Objective To investigate the expression of CK2α'in hepatocellular carcinoma(HCC)tissues and its prognosis value.Methods Tissue microarray was made from tumor and adjacent normal tissues of 83 patients with HCC.Immunohistochemical was used to stain the microarray for semi-quantitative analysis,and the expression of CK2α'in HCC tissues and adjacent normal tissues was compared.The associations between CK2α'expression and clinicopathologic features of HCC patients were analyzed withχ^(2) text.The prognostic value of CK2α'was estimated using Kaplan-Meier approach.Results The average positive expression rate of CK2α'was 47.8%in HCC and 65.4%in adjacent normal tissues.The positive expression rate of CK2α'in HCC tissues was lower than that in adjacent normal tissues(P<0.01).The expression level of CK2α'in the cancer tissues of 74.7%cases was significantly lower than that in the adjacent tissues.HCC patients with low CK2α'expression had higher risk of recurrence and shorter overall survival time(P<0.05).The expression of CK2α'was significantly correlated with CK19(P<0.05).Conclusion CK2α'is down-regulated in HCC tissues and correlated with the prognosis of patients.It could be a potential prognostic marker for HCC.