PTBP1与肿瘤发展和治疗关系的研究进展

Research Progress on Relation Between BTBP1 and Tumor Progression and Treatment

多聚嘧啶区结合蛋白1(PTBP1,也被称为hnRNP I)是一种研究广泛的RNA结合蛋白,参与调控mRNA剪接、翻译、稳定性和定位。PTBP1可参与多种非编码RNA的作用过程,影响肿瘤的发生与发展。在肿瘤治疗方面,PTBP1可能作为关键因子影响靶向药物作用靶点以及肿瘤耐药性。本文就PTBP1在肿瘤中的作用及其在肿瘤治疗中的研究进展作一综述。

PTBP1,a widely-studied RNA binding protein,regulates mRNA splicing,translation,stability and localization.PTBP1 participates in a variety of ncRNA acting processes,affects tumorigenesis and tumor progression.In terms of tumor therapy,PTBP1 may act as a key factor to affect the target of targeted drugs and influence tumor resistance.This article reviews the role of PTBP1 in tumor and its research progress in tumor treatment.