影响前列腺癌侵袭能力的相关因素分析

Analysis of Related Factors Affecting the Invasion Ability of Prostate Cancer

目的 分析影响前列腺癌侵袭能力的相关因素。方法 以我院2017年1月1日-2020年12月31日收治的111例前列腺癌患者病历为研究资料,按病灶是否转移分为局限组(n=46)和转移组(n=65),比较两组年龄、血尿程度、包膜浸润、盆腔淋巴结增生、游离前列腺特异性抗原(fPSA)、结合前列腺特异性抗原(cPSA)、总前列腺特异抗原(t PSA)、f/tPSA、前列腺特异性抗原密度(PSAD)、穿刺阳性针数、穿刺肿瘤体积占比,对差异有统计学意义因素Logistic回归分析。结果 Logistic回归分析fPSA≥10ng/mL、cPSA≥10ng/mL、tPSA≥20ng/mL、f/tPSA<0.16、穿刺肿瘤体积占比≥70%为影响前列腺癌侵袭能力的独立危险因素(P <0.05)。结论 影响前列腺癌侵袭能力因素较多,对符合条件者应予以重点关注,以便通过早期治疗提高其生存率并改善预后。

Objective To analyze the related factors affecting the invasion ability of prostate cancer.Methods The medical records of 111 patients with prostate cancer treated in the hospital were collected as the research data, and the patients were divided into localized group(n =46) and metastatic group(n =65) according to whether the lesion metastasis occurred. The age, degree of hematuria, capsular infiltration, pelvic lymph node hyperplasia, free prostate specific antigen(fPSA), complex prostate specific antigen(cPSA), total prostate specific antigen(tPSA), f/tPSA, prostate specific antigen density(PSAD), the number of positive biopsy and percentage of tumor puncture volume were compared between the two groups. Logistic regression analysis was performed on the factors with statistical significance. Results Logistic regression analysis showed that fPSA≥10 ng/mL, cPSA≥10 ng/mL,tPSA≥20 ng/mL, f/tPSA<0.16 and percentage of tumor puncture volume≥70% were independent risk factors affecting the invasion ability of prostate cancer(P <0.05). Conclusion There are many factors that affect the invasion ability of prostate cancer, and it is necessary to pay special attention to eligible people in order to enhance the survival rate and improve the prognosis through early treatment.