中西医结合治疗溃疡性结肠炎患者疗效及对血小板、凝血功能及炎性因子的影响

Impact of Integrated Chinese and Western Medicine on the Treatment Efficacy, Blood Platelet, Coagulation Function and Inflammatory Factors of Ulcerative Colitis Patients

目的 探讨对溃疡性结肠炎(ulcerative colitis, UC)患者采用中西医结合治疗的临床效果。方法选取本院于2019年1月-2020年10月收治的114例UC患者为研究对象,采用均等单盲法分为对照组和研究组,各57例,对照组单纯采用西医治疗,研究组采用中西医结合治疗,比较两组治疗效果、血小板、凝血功能和炎性因子间的差异。结果 研究组治疗总有效率高于对照组(P <0.05)。研究组治疗前血小板计数(PLT)、凝血功能指标和炎性因子水平对比无明显区别(P>0.05);研究组治疗后凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)水平与对照组无明显区别(P>0.05);研究组治疗后PLT、血浆纤维蛋白原(Fib)水平和炎性因子水平均低于对照组(P <0.05)。结论 采用中西医结合治疗UC患者不仅可以抑制机体的炎症反应,还可以有效纠正患者凝血纤溶功能失衡的现象,临床治疗效果更加显著。

Objective To study the clinical effects of integrated Chinese and western medicine for ulcerative colitis(UC) patients. Methods 114 UC patients treated from January 2019 to October 2020 in our hospital were chosen as research subjects. According to single blind method, patients were divided into control group(57 cases) and research group(57 cases). The control group took the western medicine;the research group took the integrated Chinese and western medicine. After one month, the treatment efficacy, blood platelet, coagulation function and inflammatory factors were compared. Results The total effective rate in the research group(89.47%) was higher than control group(73.68%)(P < 0.05);before treatment, the blood platelet count(PLT), coagulation function indicators and inflammatory factors between groups were not significantly different(P >0.05);after treatment, prothrombin time(PT) and activated partial thromboplastin time(APTT) between groups were not significantly different(P >0.05);after treatment, PLT, plasma fibrinogen(Fib) and inflammatory factors levels in the research group were lower than control group(P <0.05). Conclusion The integrated Chinese and western medicine can inhibit the inflammatory response, correct the blood coagulation and plasmin imbalance and increase the treatment efficacy for ulcerative colitis patients.