化痰开痹汤辅助治疗冠心病患者的效果及对其心功能和脑利钠肽水平的影响

Effect and Effect on Cardiac Function and Brain Natriuretic Peptide Levels of an Adjunctive Treatment of Huanyankaibi Decoction in Patients with Coronary Heart Disease

目的 探讨化痰开痹汤辅助治疗冠心病患者的效果及对其心功能和脑利钠肽水平的影响。方法 选取2018年3月-2020年1月肇庆市第一人民医院收治的100例冠心病同时并发高血压的患者,通过随机数字表法将其分为对照组(n=50,给予氨氯地平治疗),观察组(n=50,在对照组基础上增加化痰开痹汤辅助治疗),比较两组患者的临床效果、心功能指标、血清相关因子的表达水平以及不良反应的发生情况。结果 观察组有效率为92.00%(46/50)高于对照组76.00%(38/50)(P<0.05);观察组左室舒张末期内径(LVEDd)、左室收缩末期内径(LVESD)低于对照组,左室射血分数(LVEF%)高于对照组(P<0.05);两组血清相关因子(超敏C-反应蛋白(HsCRP)及脑钠肽(BNP))水平下降,且观察组低于对照组(P<0.05);治疗期间,观察组不良反应发生率为2/50(4.00%)低于对照组5/50(10.00%)(P>0.05)。结论 对于冠心病同时并发高血压的患者应用化痰开痹汤辅助治疗在总有效率等方面表现出明显优势,心功能有所提高,可有效调节炎症水平,不良反应对比无显著差异。

Objective To evaluate the effect and effect on cardiac function and brain natriuretic peptide levels of an adjuvant treatment of Chinese patients with coronary heart disease(CHD) using yuanyankaibi decoction. Methods A total of 100 patients with CHD and hypertension who were admitted to our hospital from March 2018 to January 2020 were selected, and the included patients were divided into 2 groups by the random number table method, which was a total of 50 patients in the control group were given amlodipine treatment, and a total of 50 patients in the observation group were given the adjuvant treatment of yuanyankaibi Decoction added to the control group, after the administration, to compare the clinical effects, cardiac function indicators, and serum relatedThe expression levels of factors as well as the occurrence of adverse effects. Results The response rate of the observation group was 92.00%(46/50)which was significantly higher than that of the control group 76.00%(38/50)(P<0.05). In the observation group, the left ventricular end diastolic diameter(LVEDd) and left ventricular end systolic diameter(LVESD) were lower than those of the control group, and the left ventricular ejection fraction(LVEF%)was higher than that of the control group(P <0.05). Two serum related factors(hypersensitive C-reactive protein(hs CRP) and brain natriuretic peptide(BNP)) levels were decreased in the observation group compared to the control group(P <0.05). During treatment, the incidence of adverse effects was 2/50(4.00%)in the observation group compared to 5/50(10.00%) in the control group(P >0.05). Conclusion Ste adjuvant treatment of huanyankaibi Decoction for patients with coronary heart disease and hypertension exhibited obvious advantages in terms of total effective rate and improved cardiac function, which could effectively regulate the level of inflammation, with no significant difference in the contrast of adverse effects.