艾普拉唑注射液联合凝血酶治疗慢性胃炎合并消化性溃疡出血的临床疗效观察

Clinical Observation of Iprazole Injection Combined with Thrombin in the Treatment of Chronic Gastritis Complicated with Peptic Ulcer Bleeding

目的 探讨艾普拉唑注射液联合凝血酶治疗慢性胃炎合并消化性溃疡出血的临床疗效。方法 选取广东省湛江市遂溪县人民医院2018年5月-2020年5月收治的100例慢性胃炎合并消化性溃疡出血患者,遵循随机双盲原则以随机数字表将患者分为两组,各50例。患者在收治入院后接受常规内镜止血治疗,此基础上对照组以奥美拉唑注射液联合凝血酶治疗,观察组采用艾普拉唑联合凝血酶治疗。对比两组治疗疗效、止血情况、血清实验室指标及不良反应。结果 观察组治疗总有效率为96.00%(48/50),对照组治疗总有效率80.00%(40/50),观察组治疗总有效率高于对照组(P<0.05)。观察组止血时间短于对照组,出血量少于对照组,差异有统计学意义(P<0.05)。治疗前两组血红蛋白、超氧化物酶指标对比差异不显著(P>0.05);治疗后观察组血红蛋白、超氧化物酶指标水平高于对照组,差异有统计学意义(P<0.05)。观察组皮疹、恶心呕吐、头痛等不良反应总发生率为8.00%(4/50),对照组皮疹、恶心呕吐、头痛等不良反应总发生率为10.00%(5/50),两组对比差异不显著(P>0.05)。结论 采用艾普拉唑注射液联合凝血酶治疗慢性胃炎合并消化性溃疡出血的疗效好于奥美拉唑注射液联合凝血酶,可有效减少患者的出血量,缩短患者的出血时间,提升血红蛋白、超氧化物酶水平,并且安全性高。

Objective To investigate the clinical efficacy of iprazole injection combined with thrombin in the treatment of chronic gastritis complicated with peptic ulcer bleeding.Methods 100 patients with chronic gastritis complicated with peptic ulcer bleeding treated in our hospital from May 2018 to may 2020 were selected.Following the principle of random double-blind,the patients were divided into two groups with 50 cases in each group.The patients received routine endoscopic hemostasis after admission.On this basis,the control group was treated with omeprazole injection combined with thrombin,and the observation group was treated with iprazole combined with thrombin.The therapeutic efficacy,hemostasis,serum laboratory indexes and adverse reactions were compared between the two groups.Results The total effective rate was 96.00% (48/50) in the observation group and 80.00% (40/50) in the control group.The total effective rate in the observation group was higher than that in the control group (P<0.05).The hemostatic time of the observation group was shorter than that of the control group,and the amount of bleeding was less than that of the control group (P<0.05).There was no significant difference in hemoglobin and superoxide enzyme between the two groups before treatment (P>0.05);After treatment,the levels of hemoglobin and superoxide enzyme in the observation group were significantly higher than those in the control group (P<0.05).The total incidence of adverse reactions such as rash,nausea,vomiting and headache in the observation group was 8.00% (4/50),and that in the control group was 10.00% (5/50).There was no significant difference between the two groups (P>0.05).Conclusion The efficacy of iprazole injection combined with thrombin in the treatment of chronic gastritis complicated with peptic ulcer bleeding is better than omeprazole injection combined with thrombin.It can effectively reduce the amount of bleeding,shorten the bleeding time,improve the levels of hemoglobin and superoxide enzyme,and has high safety.