抗链O,CCP抗体、RF和CRP联合检测在早期诊断类风湿关节炎中的作用分析

Effect Analysis of Combined Detection of Anti Chain O,CCP Antibody,RF and CRP in Early Diagnosis of Rheumatoid Arthritis

目的 探讨分析在类风湿关节炎早期诊断中应用抗链O,CCP抗体、CRP及RF联合检测的作用价值。方法 试验组165例分析对象选取为河北燕达医院2018年5月-2019年12月间收治的类风湿关节炎患者,将同期165例非类风湿关节炎自身免疫疾病患者纳入参比组中。两组均实施抗链O、CCP抗体、CRP、RF联合检测。比对分析组间患者CRP、RF、抗链O、CCP抗体检测阳性率。结果 两组抗链O检测阳性率比较差异无统计学分析意义(P>0.05);试验组CRP、RF、CCP抗体检测阳性率均高于参比组,两组数据经统计学检验提示差异具备统计学分析意义(P<0.05);试验组CRP、RF、抗链O、CCP抗体水平均高于参比组,两组数据经统计学检验提示差异具备统计学分析意义(P<0.05)。结论 在类风湿关节炎早期诊断中应用CCP抗体检测能够取得理想检测效果,将RF与CRP联合检测能够提升类风湿关节炎诊断准确性,而抗链O诊断类风湿关节炎的价值不够显著。

Objective To explore and analyze value of combined detection of anti chain o,CCP antibody,CRP and RF in early diagnosis of rheumatoid arthritis.Methods The paper chose 165 cases rheumatoid arthritis patients treated in our hospital from May 2018 to December 2019 as experimental group,and 165 patients with non rheumatoid arthritis autoimmune diseases during the same period as reference group.Anti chain o,CCP antibody,CRP and RF were detected in both groups,positive rates of CRP,RF,anti chain O and CCP antibodies were compared between groups.Results There was no significant difference in positive rate of anti chain o test between two groups (P>0.05);positive rates of CRP,RF and CCP antibodies in test group were higher than reference group.Data between two groups were statistically significant (P<0.05);levels of CRP,RF,anti chain O and CCP antibodies in experimental group were higher than reference group.Statistical test showed that difference between two groups was statistically significant (P<0.05).Conclusion CCP antibody detection can achieve ideal detection effect in early diagnosis of rheumatoid arthritis.Combined detection of RF and CRP can improve diagnostic accuracy of rheumatoid arthritis,and value of anti chain O can not achieve significant effect in diagnosis of rheumatoid arthritis.