中药足浴法联合吡贝地尔治疗透析患者不宁腿综合征临床研究

Clinical study of Treatment of Uremic Restless Legs Syndrome in Dialysis Patients with Chinese Medicine Foot Bath Combined with Piribedil

目的观察中药足浴法联合吡贝地尔治疗透析患者不宁腿综合征(uremic restless legs syndrome,u-RLS)的临床疗效。方法选取60例透析患者伴不宁腿综合征(包括血液透析和腹膜透析),随机将其分成治疗组(30例)与对照组(30例)。对照组予吡贝地尔50 mg睡前口服,治疗组在对照组的基础上同时进行中药足浴,疗程为4周。比较两组患者国际不宁腿综合征自评量表(IRLSSG)评分、匹兹堡睡眠质量指数(PSQI)评分及临床疗效,观察治疗期间药物的不良反应及血生化相关指标。结果治疗组的总有效率为86.67%(26/30),对照组为60.00%(18/30),比较两组的有效率,差异显著(P<0.05);与治疗前相比,治疗组和对照组IRLSSG、PSQI均降低(P<0.05),且治疗组较对照组降低更显著;两组血钙(Ca)、血磷(P)、甲状旁腺激素(iPTH)治疗前后无明显变化,两组间进行比较,差异不明显(P>0.05);并对两组的不良反应发生率进行比较,差异无意义(P>0.05)。结论中药足浴法联合吡贝地尔治疗透析患者伴不宁腿综合征的疗效较显著,可以明显缓解临床症状,改善睡眠质量。

Objective To observe the clinical efficacy of Chinese medicine foot bath combined with piribedil in the treatment of uremic restless legs syndrome(u-RLS)in dialysis patients.Methods 60 dialysis patients with restless legs syndrome(including hemodialysis and peritoneal dialysis)were randomly divided into treatment group(30 cases)and control group(30 cases).The control group was given piribedil 50 mg orally before going to bed,while the treatment group was given traditional Chinese medicine foot bath on the basis of the control group for 4 weeks.The scores of international restless legs syndrome self rating scale(IRLSSG),Pittsburgh sleep quality index(PSQI)and clinical efficacy were compared between the two groups.The adverse reactions of drugs and related blood biochemical indexes were observed during the treatment.Results The total effective rate was 86.67%(26/30)in the treatment group and 60.00%(18/30)in the control group.There was significant difference between the two groups(P<0.05);Compared with that before treatment,IRLSSG and PSQI in the treatment group and the control group decreased(P<0.05),and the decrease in the treatment group was more significant than that in the control group;There were no significant changes in serum calcium(Ca),serum phosphorus(P)and parathyroid hormone(iPTH)in the two groups before and after treatment.There was no significant difference between the two groups(P>0.05);There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Traditional Chinese medicine foot bath combined with piribedil has a significant effect on dialysis patients with restless legs syndrome,which can significantly alleviate clinical symptoms and improve sleep quality.