低频脉冲电刺激结合鼠神经生长因子治疗周围性面神经麻痹的疗效观察

Curative effectiveness of low frequency pulse electrical stimulation combined with mouse nerve growth factor injection in the treatment of peripheral facial paralysis

目的:探讨低频脉冲电刺激联合注射用鼠神经生长因子肌肉注射治疗周围性面神经麻痹(PFP)的临床疗效及对患者面神经功能、红细胞免疫粘附功能、超氧化物歧化酶(SOD)的影响。方法:选择2020年5月~2021年9月期间本院收治的PFP患者150例为研究对象,采用随机数字表法分为联合组(75例)和对照组(75例),对照组给予肌肉注射鼠神经生长因子治疗,联合组在对照组的基础上给予低频脉冲电刺激治疗,评价2种治疗的临床疗效及对患者面神经功能、红细胞免疫功能、SOD的影响。结果:疗程结束后,临床总有效率比较,联合组明显高于对照组(97.33%、77.33%,P<0.05)。与治疗前比较,治疗后2组瞬目反射(BR)潜伏期、面神经复合肌肉动作电位(CMAP)波幅明显降低(P<0.05),面神经指数、面神经功能评分、红细胞免疫复合物花环率(RBC-ICR)及SOD明显升高(P<0.05)。治疗后2组比较,联合组BR潜伏期、CMAP波幅水平低于对照组(P<0.05),神经指数、面神经功能评分、RBC-ICR及SOD高于对照组(P<0.05)。结论:采用低频脉冲电刺激联合注射用鼠神经生长因子治疗可显著改善PFP患者的面神经功能、红细胞免疫粘附功能和增强机体对抗自由基损伤能力,提高PFP的临床疗效。

Objective:To explore the clinical efficacy of low frequency pulse electrical stimulation combined with intramuscular injection of mouse nerve growth factor in the treatment of peripheral facial paralysis(PFP)and its effect on facial nerve function,erythrocyte immune adhesion function and superoxide dismutase(SOD).Methods:Totally,150 cases of PFP admitted to our hospital from May 2020 to September 2021 were selected as the research objects.They were randomly divided into the combined group(75 cases)and the control group(75 cases).The control group was given intramuscular injection of mouse nerve growth factor,and the combined group was given low-frequency pulse electrical stimulation on the basis of the control group.The clinical efficacy of low frequency pulse electrical stimulation combined with intramuscular injection of mouse nerve growth factor,and its effect on facial nerve function,erythrocyte immune function and SOD in two groups were evaluated.Results:After treatment,the total effective rate in the combined group was 97.33%(73/75),significantly higher than 77.33%(58/75)in the control group(P<0.05).Compared with those before treatment,blink reflex(BR)latency and facial nerve compound muscle action potential(CMAP)amplitude were significantly decreased,facial nerve index,erythrocyte immune complex rosette rate(rbc-icr)and SOD were significantly increased in the two groups after treatment(P<0.05).After treatment,the levels of BR latency and CMAP amplitude in the combined group were lower than those in the control group,and the nerve index,facial nerve function score,rbc-icr and SOD in the combined group were higher than those in the control group(P<0.05).Conclusion:Low frequency pulse electrical stimulation combined with mouse nerve growth factor injection can significantly improve the facial nerve function,erythrocyte immune adherence function,enhance the body’s ability to resist free radical injury,and improve the clinical efficacy of PFP.