不同血液净化方式对维持性血液透析患者治疗效果及生活质量的影响研究

Effect of Different Blood Purification Methods on Treatment Effect and Quality of Life of Patients with Maintenance Hemodialysis

目的研究维持性血液透析患者治疗中不同血液净化方式的效果及对患者生活质量的影响。方法回顾性选取2020年2月-2021年2月本院维持性血液透析患者100例,依据血液净化方式分为血液透析联合血液灌流(研究组)、低通量血液透析(对照组)两组,各50例,统计分析两组患者治疗前后的肾功能、骨代谢指标、微炎症状态、营养状态、生活质量。结果两组患者治疗后的SCr、BUN、RRF水平均低于治疗前(P<0.05);治疗后,研究组患者的SCr、BUN、RRF水平均低于对照组(P<0.05)。两组患者治疗后的P、Ca水平均高于治疗前(P<0.05),iPTH水平均低于治疗前(P<0.05);治疗后,研究组患者的P、Ca水平均高于对照组(P<0.05),iPTH水平均低于对照组(P<0.05)。两组患者治疗后的β2-M、CRP、IL-6水平均低于治疗前(P<0.05);治疗后,研究组患者的β2-M、CRP、IL-6水平均低于对照组(P<0.05)。两组患者治疗后的ALB、Hb水平、SF-36评分均高于治疗前(P<0.05);治疗后,研究组患者的ALB、Hb水平、SF-36评分均高于对照组(P<0.05)。结论维持性血液透析患者治疗中血液透析联合血液灌流的效果较低通量血液透析好,更能有效提升患者生活质量,值得推广。

Objective To study the effect of different blood purification methods in the treatment of maintenance hemodialysis patients and the influence on the quality of life of patients.Methods A total of 100 patients with maintenance hemodialysis in Xianning First People’s Hospital from February 2020 to February 2021 were retrospectively selected.According to the blood purification methods,they were divided into two groups:hemodialysis combined with hemoperfusion(study group)and lowthroughput hemodialysis(control group),with 50 patients in each group.The renal function,bone metabolism indexes,micro-inflammatory status,nutritional status and quality of life in 2 groups before and after treatment were statistically analyzed.Results The levels of Scr,BUN and RRF in 2 groups after treatment were lower than before treatment(P<0.05).After treatment,SCR,BUN and RRF levels in the study group were lower than those in the control group(P<0.05).The levels of P and Ca in 2 groups after treatment were higher than before treatment(P<0.05),and the levels of IPTH in 2 groups were lower than before treatment(P<0.05).After treatment,the levels of P and Ca in the study group were higher than those in the control group(P<0.05),and the levels of IPTH in the study group were lower than those in the control group(P<0.05).The levels ofβ2-M,CRP and IL-6 in 2 groups after treatment were lower than before treatment(P<0.05).After treatment,the levels ofβ2-M,CRP and IL-6 in the study group were lower than those in the control group(P<0.05).The levels of ALB,HB and SF-36 in 2 groups after treatment were higher than those before treatment(P<0.05).After treatment,the levels of ALB,HB and SF-36 in the study group were higher than those in the control group(P<0.05).Conclusion In the treatment of maintenance hemodialysis patients,hemodialysis combined with hemoperfusion has a better effect than low-flux hemodialysis,and can effectively improve the quality of life of patients,which is worthy of promotion.