布拉氏酵母菌散联合蒙脱石散治疗对小儿轮状病毒感染性腹泻患儿TNF-α、IL-10、IL-13水平的影响

The Effect of Bula's Yeast Powder Combined with Montmorillonite Powder on the Levels of TNF-α,IL-10 and IL-13 in Children with Rotavirus Infectious Diarrhea

目的研究布拉氏酵母菌散联合蒙脱石散治疗对小儿轮状病毒感染性腹泻患儿TNF-α、IL-10、IL-13水平的影响。方法选取信宜市妇幼保健院2019年3月-2021年5月收治的136例轮状病毒感染性腹泻患儿为研究对象,随机等分为两组,分别在常规治疗的基础上再给予不同的用药治疗,对照组68例患儿采取蒙脱石散治疗,研究组68例患儿在此基础上给予布拉氏酵母菌散治疗,治疗后观察比较两组患儿的住院时间、症状改善时间,TNF-α、IL-10及IL-13等炎性因子水平,治疗效果以及不良反应发生情况。结果研究组患儿的住院时间少于对照组,大便性状恢复正常、呕吐消失、退热、腹胀消失等时间均较对照组更短(P<0.05);此外,经治疗,研究组患儿的TNF-α、IL-13低于对照组(P<0.05),IL-10高于对照组(P<0.05);另一方面,研究组患儿的治疗效果更优,两组患儿的不良反应情况比较,差异无统计学意义(P>0.05)。结论布拉氏酵母菌散联合蒙脱石散治疗对小儿轮状病毒感染性腹泻患儿TNF-α、IL-10、IL-13水平的具有积极影响,期望具有更高的治疗有效率,值得广泛推广。

Objective To study the effect of Saccharomyces boulardii powder combined with montmorillonite powder on the levels of TNF-α,IL-10 and IL-13 in children with rotavirus infectious diarrhea.Methods 136 children with rotavirus infectious diarrhea admitted in Xinyi Maternal and Child Care Health Hospital from March 2019 to May 2021 were selected as the research subjects,they were randomly divided into two groups,and they were given different treatments on the basis of conventional treatment.The 68 children in the control group were treated with montmorillonite powder,and 68 children in the study group were treated with Saccharomyces boulardii powder on this basis.After continuous treatment,the hospitalization time,symptom improvement time,levels of inflammatory factors such as TNF-α,IL-10 and IL-13,treatment effect and occurrence of adverse reactions of the two groups of children was observed and compared.Results Patients in the study group spent less time in hospital than the control group,and the time for stool characteristics to return to normal,vomiting,fever,and abdominal distension disappeared was shorter than that of the control group(P<0.05);in addition,after treatment,the study group had TNF-αand IL-13 were lower than the control group(P<0.05),and IL-10 was higher than the control group(P<0.05);on the other hand,the treatment effect of patients in the study group was better,and there was no significant difference in adverse reaction between the two groups(P>0.05).Conclusion Saccharomyces boulardii powder combined with montmorillonite powder has a positive effect on the levels of TNF-α,IL-10,and IL-13 in children with rotavirus infectious diarrhea.It is expected that it will have a higher therapeutic efficiency.It is worthy of widespread promotion.