摘要
三环己基氢氧化锡与4-吡啶甲酸按物质的量比1∶1在乙醇溶剂中反应,合成了水合三环己基锡4-吡啶甲酸酯配合物。采用元素分析、红外光谱、核磁共振、差热分析和X-射线单晶衍射等对配合物进行了结构表征,并对配合物进行量子化学计算和体外抗癌活性研究。结果表明:配合物中心锡原子为五配位畸变三角双锥构型;配合物对人肝癌细胞(HUH7)、人肺腺癌细胞(A549)、人表皮癌细胞(A431)和人结肠癌细胞(HCT-116)的抑制活性高于顺铂。
The hydrated tricyclohexyltin 4-pyridinecarboxylate complex was synthesized by the reaction of tricyclohexyltin hydroxide and 4-pyridinecarboxylic acid in ethanol solvent.The structure of the complex was characterized by elemental analysis,IR,1H NMR,differential thermal analysis and X-ray single crystal diffraction.The study on the complex has been performed with quantum chemistry calculation and in vitro anticancer activity.The results show that the complex is in a central tin pentagonal distorted triangular biconical configuration.The complex showed stronger inhibitory activity than cisplatin in clinical use on human liver cancer cells(HuH7),human lung cancer cells(A549),human epidermal cancer cells(A431)and human colon cancer cells(HCT-116).
作者
何丽芳
张复兴
李宗泽
王芳宇
刘最
陈佩云
HE Lifang;ZHANG Fuxing;LI Zongze;WANG Fangyu;LIU Zui;CHEN Peiyun(Hunan Key Laboratory for Conservation and Utilization of Biological Resources in the Nanyue Mountainous Region, College of Life Sciences, Hengyang Normal University, Hengyang 421008, China;Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang 421008, China)
出处
《合成化学》
CAS
2022年第7期521-526,共6页
Chinese Journal of Synthetic Chemistry
基金
湖南省教育厅重点项目(19A070)
湖南省自然科学青年基金资助项目(2021JJ40010)
湖南省自然科学基金资助项目(2019JJ60022,2020JJ6042)
湖南省高校创新平台开放基金资助项目(18K089)
衡阳师范学院大学生创新创业训练计划项目(cxcy2021034)。
关键词
水合三环己基锡4-吡啶甲酸酯配合物
晶体结构
量子化学
体外抗肿瘤活性
合成
构型
hydrated tricyclohexyltin 4-pyridinecarboxylate complex
crystal structure
quantum chemistry
in vitro antitumor activity
synthesize
configuration
