乳腺癌患者血液学参数与HER-2表达的关系

Correlation of hematological indexes and expression of HER-2 in patients with breast cancer

目的探讨乳腺癌患者人类表皮生长因子受体2(HER-2)表达与血液学参数的关系。方法选取浸润性乳腺癌患者133例,根据HER-2检测结果分为HER-2阴性组(92例)和HER-2阳性组(41例),比较2个组临床病理特征和血液学参数的差异。结果与HER-2阴性组比较,HER-2阳性组红细胞体积分布宽度(RDW)明显升高,血小板体积分布宽度(PDW)明显降低(P<0.05)。RDW和PDW鉴别诊断HER-2阳性和HER-2阴性乳腺癌的最佳临界值分别为13.35%和49.70 fL。HER-2表达与淋巴结转移有关(P<0.05)。高水平RDW(≥13.35%)、低水平PDW(<49.70 fL)与乳腺癌组织HER-2表达有关(P<0.05)。结论RDW、PDW与乳腺癌患者的HER-2表达有关,对于乳腺癌的病情评估、预后评价和治疗方案的选择具有重要参考价值。

Objective To investigate the correlation of hematological indexes and expression of human epidermal growth factor receptor-2(HER-2)in patients with breast cancer.Methods Totally,133 patients with invasive breast cancer were enrolled,and they were classified into HER-2 positive group(41 cases)and HER-2 negative group(92 cases).The clinical characteristics and hematological indexes were compared between the 2 groups.Results Compared with HER-2 negative group,HER-2 positive group had a higher red cell volume distribution width(RDW)and a lower platelet distribution width(PDW)(P<0.05).The optimal cut-off values of RDW and PDW for the differential diagnosis of HER-2 expression were 13.35%and 49.70 fL,respectively.The expression of HER-2 was correlated with lymph node metastasis(P<0.05).A high level of RDW(≥13.35%)and a low level of PDW(<49.70 fL)were correlated with HER-2 expression in breast cancer tissues(P<0.05).Conclusions RDW and PDW are correlated with HER-2 expression in breast cancer tissues,and they provide a reference for the differential diagnosis of benign and malignant breast cancer.