妊娠期妇女产前筛查对于严重先天性缺陷儿宫内诊断的临床价值分析

Analysis of the clinical value of prenatal screening in pregnant women for intrauterine diagnosis of fetus with severe congenital defects

目的分析妊娠期妇女产前筛查对于严重先天性缺陷儿宫内诊断的临床价值。方法3572例妊娠期妇女为研究对象,根据是否同意且接受产前筛查分为筛查组(同意且接受产前筛查,2983例)与未筛组(不接受产前筛查,589例)。筛查组进行产前筛查,观察严重先天性缺陷儿筛查结果,随访并比较两组严重先天性缺陷儿出生情况。结果筛查组筛查出严重先天性缺陷儿81例(2.72%),其中42例(1.41%)胎儿感染、23例(0.77%)先天畸形、11例(0.37%)染色体病和5例(0.17%)单基因病。筛查组分娩出严重先天性缺陷儿2例(0.07%),均为胎儿感染。未筛组分娩出严重先天性缺陷儿16例(2.72%),其中9例(1.53%)胎儿感染、3例(0.51%)先天畸形、3例(0.51%)染色体病和1例(0.17%)单基因病。筛查组严重先天性缺陷儿出生率0.07%低于未筛组的2.72%,差异有统计学意义(P<0.05)。结论妊娠期妇女进行产前筛查,可以明显降低严重先天性缺陷儿的出生率,具有较高的宫内诊断价值。

Objective To analyze the clinical value of prenatal screening in pregnant women for intrauterine diagnosis of fetus with severe congenital defects.Methods A total of 3572 pregnant women as study subjects were divided into screening group(2983 women who agreed to undergo prenatal screening)and non-screening group(589 women who did not undergo prenatal screening)according to whether they agreed to undergo prenatal screening.The screening results of children with severe congenital defects were observed,and the birth status of the two groups of children with severe congenital defects was followed up and compared.Results I n the screening group,there were 81 cases(2.72%)of severe congenital defects,including 42 cases(1.41%)of fetal infections,23 cases(0.77%)of congenital malformations,11 cases(0.37%)of chromosomal disease and 5 cases(0.17%)of monogenic disease.2 cases(0.07%)of severe congenital defects were delivered in the screening group,both of which were fetal infections.In the non-screening group,there were 16 cases(2.72%)of severe congenital defects,including 9 cases(1.53%)of fetal infections,3 cases(0.51%)of congenital malformations,3 cases(0.51%)of chromosomal disease and 1 case(0.17%)of monogenic disease.The birth rate of severe congenital defects in the screening group was 0.07%,which was lower than 2.72%in the non-screening group,and the difference was statistically significant(P<0.05).Conclusion Prenatal screening for pregnant women can significantly reduce the birth rate of severe congenital defects,and has a high intrauterine diagnostic value.