盐酸胺碘酮治疗急性心肌梗死后室性心律失常的临床疗效观察

Clinical efficacy of amiodarone hydrochloride in the treatment of ventricular arrhythmia after acute myocardial infarction

目的分析盐酸胺碘酮治疗急性心肌梗死后室性心律失常的临床疗效。方法70例急性心肌梗死后室性心律失常患者,依据随机数字表法分为观察组与对照组,每组35例。对照组给予利多卡因治疗,观察组给予盐酸胺碘酮治疗。比较两组不良反应发生情况、治疗前后心律失常次数、心房除极波起点至终点的时间(QPS波时限)、心房除极到心室除极开始的时间(PR间期)、脑钠肽(BNP)、磷酸肌酸激同工酶(CK-MB)及治疗效果。结果观察组不良反应发生率5.71%低于对照组的34.29%,差异有统计学意义(P<0.05)。治疗后,两组心律失常次数、QPS波时限、PR间期、BNP及CK-MB水平均优于本组治疗前,且观察组心律失常次数(4166.21±123.21)次/年、QPS波时限(0.04±0.01)s、PR间期(0.12±0.01)s、BNP(101.50±10.12)pg/ml、CK-MB(43.19±5.01)U/L,均优于对照组的(5966.66±245.56)次/年、(0.08±0.02)s、(0.15±0.01)s、(168.56±15.56)pg/ml、(63.69±9.61)U/L,差异均有统计学意义(P<0.05)。结论急性心肌梗死后室性心律失常患者给予盐酸胺碘酮治疗的治疗效果确切,可改善心律失常,改善心功能状况,且安全性高,值得推广和应用。

Objective To analyze the clinical efficacy of amiodarone hydrochloride in the treatment of ventricular arrhythmia after acute myocardial infarction.Methods A total of 70 patients with ventricular arrhythmia after acute myocardial infarction were divided into observation group and control group according to random numerical table,with 35 cases in each group.The control group was treated with lidocaine,and the observation group was treated with amiodarone hydrochloride.The occurrence of adverse reactions,the number of arrhythmias,time from the start of the QRS complex to the end of the QRS complex(QPS wave time limit),the time from atrial depolarization to the onset of ventricular depolarization(PR interval),and brain natriuretic peptide(BNP)and creatine phosphate kinase isoenzyme(CK-MB)before and after treatment,and therapeutic effect were compared between the two groups.Results The incidence of adverse reactions 5.71%in the observation group was lower than 34.29%in the control group,and the difference was statistically significant(P<0.05).After treatment,the number of arrhythmias,the QPS wave time limit,PR interval,BNP level and CK-MB in the two groups were better than those before treatment in this group;the number of arrhythmias in the observation group was(4166.21±123.21)times/year,the QPS wave time limit was(0.04±0.01)s,the PR interval was(0.12±0.01)s,the BNP was(101.50±10.12)pg/ml,the CK-MB was(43.19±5.01)U/L,which were better than(5966.66±245.56)times/year,(0.08±0.02)s,(0.15±0.01)s,(168.56±15.56)pg/ml,(63.69±9.61)U/L in the control group;all the differences were statistically significant(P<0.05).Conclusion Amiodarone hydrochloride is effective in the treatment of ventricular arrhythmia after acute myocardial infarction.It can improve arrhythmia and cardiac function,and has high safety.It is worthy of popularization and application.