脑苷肌肽联合丁苯酞治疗急性脑梗死患者的效果

Effects of Cerebroside carnosine combined with Butylphthalide in treatment of patients with acute cerebral infarction

目的:观察脑苷肌肽联合丁苯酞治疗急性脑梗死患者的效果。方法:选取78例急性脑梗死患者为研究对象,以抽签法随机分为对照组和观察组各39例。对照组采用丁苯酞治疗,观察组在对照组基础上联合脑苷肌肽治疗,比较两组临床疗效、治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数评分、血清学指标[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、血管内皮生长因子(VEGF)]水平和后遗症发生率。结果:观察组治疗总有效率为94.9%(37/39),高于对照组的76.9%(30/39),差异有统计学意义(P<0.05);治疗7、14 d后,观察组NIHSS评分低于对照组,Barthel指数评分高于对照组,差异均有统计学意义(P<0.05);治疗后,两组TNF-α、IL-6水平均低于治疗前,且观察组低于对照组,两组VEGF水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);观察组后遗症发生率为2.6%(1/39),低于对照组的20.5%(8/39),差异有统计学意义(P<0.05)。结论:脑苷肌肽联合丁苯酞治疗急性脑梗死患者可提高治疗总有效率和Barthel指数评分,改善血清学指标水平,降低NIHSS评分和后遗症发生率,效果优于单纯丁苯酞治疗。

Objective:To observe effects of Cerebroside carnosine combined with Butylphthalide in treatment of patients with acute cerebral infarction.Methods:78 patients with acute cerebral infarction were selected as the research objects and were randomly divided into control group and observation group by drawing lots,39 cases in each group.The control group was treated with Butylphthalide,while the observation group was treated with Cerebroside carnosine on the basis of that of the control group.The clinical effects,the National Institutes of Health Stroke Scale(NIHSS)score,the Barthel index score,the serological index levels[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),vascular Endothelial growth factor(VEGF)]and incidence of sequelae were compared between the two groups.Results:The total effective rate of the observation group was 94.9%(37/39),which was higher than 76.9%(30/39)of the control group,and the difference was statistically significant(P<0.05).After 7 and 14 days of treatment,the NIHSS score of the observation group was lower than that of the control group;the Barthel index score was higher than that of the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of TNF-αand IL-6 in the two groups were lower than before the treatment,and those of the observation group were lower than those of the control group;the levels of VEGF in the two groups were higher than before the treatment,and that of the observation group was higher than that of the control group;and the differences were statistically significant(P<0.05).Further,the incidence of sequelae in the observation group was 2.6%(1/39),which was lower than 20.5%(8/39)in the control group,and the difference was statistically significant(P<0.05).Conclusions:Cerebroside carnosine combined with Butylphthalide in the treatment of the patients with acute cerebral infarction can improve the total effective rate and the Barthel index score,improve the levels of serological indexes,and reduce the NIHSS score and the incidence of sequelae.Moreover,it is superior to single Butylphthalide treatment.