补阳还五汤合清脑方联合阿司匹林肠溶片治疗气虚血瘀型脑梗死恢复期患者的效果

Effects of Buyang Huanwu decoction and Qingnao formula combined with Aspirin enteric-coated tablets in treatment of patients with cerebral infarction of qi deficiency and blood stasis type during recovery stage

目的:观察补阳还五汤合清脑方联合阿司匹林肠溶片治疗气虚血瘀型脑梗死(CI)恢复期患者的效果。方法:选取102例CI恢复期患者为研究对象,按照随机数字表法分为观察组与对照组各51例。对照组予以阿司匹林肠溶片治疗,观察组在对照组基础上给予补阳还五汤合清脑方治疗,比较两组疗效、中医证候积分、美国国立卫生研究院神经功能缺损量表(NIHSS)评分、Fugl-Meyer运动功能评分表(FMA)评分、Barthel指数评分、血液流变学指标(血浆黏度、全血低/高切还原黏度)水平和不良反应发生率。结果:观察组治疗总有效率为96.08%,明显高于对照组的80.39%,差异有统计学意义(P<0.05);治疗后,两组半身不遂、偏身麻木、舌歪语蹇、手足肿胀、心悸自汗和气短乏力等中医证候积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组NIHSS评分低于治疗前,且观察组低于对照组,FMA评分、Barthel指数评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组血浆黏度、全血高/低切还原黏度低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组治疗期间均未见明显不良反应。结论:补阳还五汤合清脑方联合阿司匹林肠溶片治疗气虚血瘀型CI恢复期患者可提高治疗总有效率、FMA评分和Barthel指数评分,降低中医证候积分、NIHSS评分和血液流变学指标水平,效果优于单纯阿司匹林肠溶片治疗效果。

Objective:To observe effects of Buyang Huanwu decoction and Qingnao formula combined with Aspirin enteric-coated tablets in treatment of patients with cerebral infarction(CI)of qi deficiency and blood stasis type during recovery stage.Methods:102 CI patients during THE recovery stage were selected as the research objects,and were divided into observation group and control group according to the random number table method,51 cases in each.The control group was treated with Aspirin enteric-coated tablets,while the observation group was treated with Buyang Huanwu decoction and Qingnao formula on the basis of that of the control group.The curative effects,the TCM syndrome score,the national institute of health stroke scale(NIHSS)score,the Fugl-Meyer motor assessment(FMA)score,the Barthel index score,the hemorheologic index levels(plasma viscosity,whole blood low/high shear reduction viscosity)levels and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 96.08%,which was significantly higher than the control group of 80.39%,and the difference was statistically significant(P<0.05).After the treatment,the scores of TCM syndromes such as hemiplegia,hemianesthesia,deviated tongue and dysphasia,swelling of hands and feet,palpitations,spontaneous sweating,shortness of breath and fatigue in the two groups were lower than those before the treatment;those of the observation group were lower than those of the control group;and the differences were statistically significant(P<0.05).After the treatment,the NIHSS scores of the two groups were lower than those before the treatment,and that of the observation group was lower than that of the control group;the FMA score and the Barthel index score were higher than those before the treatment,and those of the observation group were higher than those of the control group;and the differences were statistically significant(P<0.05).After the treatment,the plasma viscosity and the whole blood high/low shear reduction viscosity of the two groups were lower than those before the treatment;those of the observation group were lower than those of the control group;and the differences were statistically significant(P<0.05).However,there were no obvious adverse reactions in the two groups during the treatment.Conclusions:Buyang Huanwu decoction and Qingnao formula combined with Aspirin enteric-coated tablets can improve the total effective rate,the FMA score and the Barthel index score and reduce the TCM syndrome score,the NIHSS score and the hemorheologic index levels in the patients with CI of qi deficiency and blood stasis type during recovery stage.Moreover,it is superior to single Aspirin enteric-coated tablets treatment.