通痹益脑汤联合常规西药治疗急性脑梗死患者的效果

Effects of Tongbi Yinao decoction combined with conventional western medicine in treatment of patients with acute cerebral infarction

目的:观察通痹益脑汤联合常规西药治疗急性脑梗死患者的效果。方法:选取80例急性脑梗死患者为研究对象,按随机数字表法将其分为观察组(n=40)和对照组(n=40)。对照组行常规西药治疗,观察组在对照组基础上联合通痹益脑汤治疗,比较两组临床疗效、治疗前后中医证候积分、血流动力学指标[大脑前动脉(ACA)、大脑后动脉(PCA)、大脑中动脉(MCA)的平均血流速度]水平、格拉斯哥预后量表(GOS)分级和不良反应发生率。结果:观察组治疗总有效率为95.00%(38/40),高于对照组的80.00%(32/40),差异有统计学意义(P<0.05);治疗后,观察组中医证候积分低于对照组,差异有统计学意义(P<0.05);观察组ACA、PCA、MCA平均血流速度均高于对照组,差异有统计学意义(P<0.05);观察组GOS分级Ⅴ级占比率高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:通痹益脑汤联合常规西药治疗急性脑梗死患者可提高治疗总有效率、血流动力学指标水平和GOS分级Ⅴ级占比率,以及降低中医证候积分,其效果优于单纯常规西药治疗。

Objective:To observe ffects of Tongbi Yinao decoction combined with conventional western medicine in treatment of patients with acute cerebral infarction.Methods:80 patients with acute cerebral infarction were selected as the research objects,and were divided into observation group(n=40)and control group(n=40)according to the random number table method.The control group was treated with conventional western medicine,while the observation group was treated with Tongbi Yinao decoction on the basis of that of the control group.The clinical efficacy,the TCM syndrome scores before and after the treatment,the hemodynamic indexes[average blood flow velocities of anterior cerebral artery(ACA),posterior cerebral artery(PCA),and middle cerebral artery(MCA)],the Glasgow outcome scale(GOS)grade and incidence of adverse reactions were compared between the two groups.Results:The total effective rate in the observation group was 95.00%(38/40),which was higher than 80.00%(32/40)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the TCM syndrome scores in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The average blood flow velocities of ACA,PCA and MCA in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The proportion of GOS grade V in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Tongbi Yinao decoction combined with conventional western medicine in the treatment of the patients with acute cerebral infarction can improve the total effective rate of treatment,the levels of hemodynamic indexes and the proportion of GOS grade V,and reduce the TCM syndrome score.Moreover,it is superior to single conventional western medicine treatment.