去氧孕烯炔雌醇与地屈孕酮治疗青春期排卵障碍性异常子宫出血患者的效果比较

Comparison of effects of Desogestrel ethinyloestradiol and Dydrogesterone in treatment of adolescent patients with anovulatory abnormal uterine bleeding

目的:比较去氧孕烯炔雌醇与地屈孕酮治疗青春期排卵障碍性异常子宫出血患者的效果。方法:回顾性分析2018年4月至2020年4月该院收治的100例青春期排卵障碍性异常子宫出血患者的临床资料,按照治疗方案不同将患者分为对照组(n=50)和研究组(n=50)。对照组采用地屈孕酮治疗,研究组采用去氧孕烯炔雌醇治疗,比较两组止血效果(出血量减半时间、完全止血时间)、调整周期月经正常率、临床疗效和不良反应发生率。结果:研究组出血量减半时间、完全止血时间均短于对照组,差异有统计学意义(P<0.05);调整周期第一疗程,两组月经正常率比较,差异无统计学意义(P>0.05);调整周期第二、三疗程,研究组月经正常率依次为50.00%(25/50)、62.00%(31/50),分别低于对照组的72.00%(36/50)、84.00%(42/50),差异有统计学意义(P<0.05);研究组治疗总有效率为94.00%(47/50),高于对照组的80.00%(40/50),差异有统计学意义(P<0.05);研究组不良反应发生率为4.00%(2/50),低于对照组的16.00%(8/50),差异有统计学意义(P<0.05)。结论:相较于地屈孕酮,去氧孕烯炔雌醇治疗青春期排卵障碍性异常子宫出血患者,可明显提高止血效果、临床疗效,降低不良反应发生率,但其影响月经正常率,临床应根据患者情况合理用药。

Objective:To compare effects of Desogestrel ethinyloestradiol and Dydrogesterone in treatment of adolescent patients with anovulatory abnormal uterine bleeding.Methods:The clinical data of 100 adolescent patients with anovulatory abnormal uterine bleeding who were admitted to our hospital from April 2018 to April 2020 were retrospectively analyzed.These patients were divided into control group(n=50)and study group(n=50)according to different treatment regimens.The control group was treated with Dydrogesterone,while the study group was treated with Desogestrel ethinyloestradiol.The hemostatic effects(the time to reduce the bleeding to 1/2 original volume,complete hemostasis time),the normal menstrual rate after adjusting the menstrual cycle,the clinical effects and the incidence of adverse reactions were compared between the two groups.Results:The time to reduce the bleeding to 1/2 original volume and the complete hemostasis time in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After adjusting the menstrual cycle for a course,there was no significant difference in the normal menstrual rate between the two groups(P>0.05).After adjusting the menstrual cycle for second and third courses of the normal menstrual rate in the study group was 50.00%(25/50)and 62.00%(31/50),which were lower than 72.00%(36/50)and 84.00%(42/50)in the control group,respectively,and the differences were statistically significant(P<0.05).The total effective rate of the study group was 94.00%(47/50),which was higher than 80.00%(40/50)of the control group,and the difference was statistically significant(P<0.05).Further,the incidence of adverse reactions in the study group was 4.00%(2/50),which was lower than 16.00%(8/50)in the control group,and the difference was statistically significant(P<0.05).Conclusions:Compared with Dydrogesterone,Desogestrel ethinyloestradiol in the treatment of the adolescent patients with anovulatory abnormal uterine bleeding can significantly improve the hemostatic effects and the clinical efficacy as well as reduce the incidence of adverse reactions,but it affects the normal menstruation rate.Therefore,it should be rationally used based on the patients’conditions.