氧化应激在炎症性肠病和结肠炎相关结直肠癌疾病中的研究进展

Research progress of oxidative stress in inflammatory bowel disease and colitis related colorectal cancer

氧化应激是近年来基础与临床研究的热点,其被认为与许多人类疾病有关,包括糖尿病肾病、心血管病变、肝纤维化、胃肠道疾病、神经退行性病变、癌症等。研究发现,在炎症性肠病(inflammatory bowel disease,IBD)及结肠炎相关结直肠癌(colitis associated colorectal cancer,CAC)的发病过程中,患者体内存在以氧化还原失衡为特征的“氧化应激”。本文旨在阐明氧化应激在促进IBD及CAC发生过程中的作用,并强调抗氧化剂的潜在保护作用,抗氧化剂在预防IBD及CAC的研究中具有重要意义,期望能为以后探索其临床应用价值提供参考。

In recent years,it is considered to be related to many basic diseases,such as diabetes,kidney disease,cardiovas cular,liver fibrosis,gastrointestinal diseases,neurodegenerative diseases,cancer and so on.Studies have found that in the pathogenesis of inflammatory bowel disease(IBD)and colitis associated colorectal cancer(CAC),patients have"oxidative stress"characterized by imbalance of redox.This article aimed to clarify the role of oxidative stress in promoting the occurrence of IBD and CAC,and emphasized the potential protective role of antioxidants.Antioxidants play an important role in the prevention of IBD and CRC,and hope to provide reference for exploring its clinical application value in the future.