突触后致密蛋白95与离子型谷氨酸受体棕榈酰化在中枢神经系统疾病中的研究进展

Research advances in palmitoylation of postsynaptic density protein 95 and ionotropic glutamate receptors in central nervous system diseases

突触可塑性的调节与离子型谷氨酸受体的活性密切相关。突触后致密蛋白95(PSD⁃95)作为一种突触后支架蛋白,对α⁃氨基⁃3⁃羟基⁃5⁃甲基⁃4⁃异恶唑丙酸受体(AMPAR)和N⁃甲基⁃D⁃天冬氨酸受体(NMDAR)为代表的离子型谷氨酸受体在突触后膜的稳定性有十分重要的作用。近年来,PSD⁃95棕榈酰化与离子型谷氨酸受体(AMPAR、NMDAR)之间的相互作用也受到了广泛关注。该综述聚焦PSD⁃95与离子型谷氨酸受体(AMPAR、NMDAR)的棕榈酰化过程,以及上述棕榈酰化过程在癫痫、阿尔茨海默病、亨廷顿病和神经元蜡样脂褐质沉积症中的研究进展,为中枢神经系统疾病的治疗提供新的研究思路。

The regulation of synaptic plasticity is closely related to the activity of the ionotropic glutamate receptor.Postsynaptic density protein 95(PSD95)is a postsynaptic scaffold protein.It plays a very important role in maintaining the stability of ionotropic glutamate receptors,such asαamino3hydroxy5methyl4isoxazolepropionic acid receptor(AMPAR)and NmethylDaspartate receptor(NMDAR),at the postsynaptic membrane.In recent years,the interaction between palmitoylation of PSD95 and ionotropic glutamate receptors(AMPAR and NMDAR)has also attracted extensive attention.This review focuses on the palmitoylation process of PSD95 and ionotropic glutamate receptors(AMPAR and NMDAR),as well as the research progress of the above palmitoylation process in epilepsy,Alzheimer’s disease,Huntington’s disease,and neuronal ceroid lipofuscinosis,so as to provide new research ideas for the treatment of central nervous system diseases.