急性脑卒中后抑郁的相关危险因素分析

Analysis on relative factors of patients with post-acute stroke depression

目的分析急性脑卒中后抑郁(PSD)的发生率及相关危险因素。方法选取2019年3月至2020年9月本院收治的303例急性脑卒中患者作为研究对象,根据汉密顿抑郁量表17项(HAMD-17)评分结果分为PSD组(n=77)和非PSD组(n=226)。采用单因素及多因素分析急性脑卒中患者PSD发生的相关危险因素。结果303例急性脑卒中患者,PSD发病率为25.41%。两组婚姻情况、家庭关系、卒中次数、病灶数目、C反应蛋白(CRP)水平、日常生活能力量表(ADL)评分及美国国立卫生研究院卒中量表(NIHSS)评分比较差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,ADL评分是PSD的保护因素,NIHSS评分是PSD的独立危险因素(P<0.05)。结论脑卒中患者PSD发病率较高,且PSD与日常生活能力和神经功能缺损程度密切相关,明确PSD发生的危险因素,有助于对疾病进行早期干预,改善患者神经功能及生活能力。

Objective To analyzee the incidence and related risk factors of acute post-stroke depression(PSD).Methods 303 patients with acute stroke treated in our hospital from March 2019 to September 2020 were selected as the research subjects,and they were divided into PSD group(n=77)and non-PSD group(n=226)according to Hamilton depression scale-17(HAMD-17).Univariate and multivariate analysis were used to analyze the related risk factors of PSD after acute stroke.Results Among 303 patients with acute stroke,the incidence rate of PSD was 25.41%.There were significant different in marriage status,family relationship,number of strokes,number of lesions,C-reactive protein(CRP)level,ability of daily living scale(ADL)score and National Institutes of Health stroke scale(NIHSS)score between the two groups(P<0.05).Multivariate logistic regression analysis showed that ADL score was protective factor for PSD,and NIHSS score was independent risk factor for PSD(P<0.05).Conclusion The incidence of PSD is high in stroke patients,and PSD is closely related to the ability of daily living and the degree of neurological deficit,identifying the risk factors for the occurrence of PSD is helpful for early intervention of the disease,which is beneficial to improve the neurological function and living ability of patients.