LDH、HMGB-1联合AChE活性检测在急性胰腺炎病情、预后评估中的应用

Values of LDH,HMGB-1 Combined with AChE Activity Detection in Evaluation of Conditions and Prognoses of Patients with Acute Pancreatitis

目的探讨乳酸脱氢酶(LDH)、高迁移率蛋白-1(HMGB-1)联合乙酰胆碱酯酶(AChE)活性检测在急性胰腺炎病情、预后评估中的价值。方法选择2017年3月—2020年8月收治的急性胰腺炎127例作为观察组,选择同期进行体检的健康者132例作为对照组。比较2组血清LDH、HMGB-1水平及AChE活性,记录患者预后情况,并分析三项指标单一检测及联合检测对急性胰腺炎预后的预测价值。结果观察组血清LDH、HMGB-1水平高于对照组,AChE活性低于对照组(P<0.01)。随着急性胰腺炎病情的加重,血清LDH、HMGB-1水平逐渐升高,AChE活性逐渐降低(P<0.05)。本组预后不良率为14.17%。预后良好组血清LDH、HMGB-1水平低于预后不良组,AChE活性高于预后不良组(P<0.01)。LDH、HMGB-1水平及AChE活性单一检测敏感度、特异度、曲线下面积均低于三者联合检测。结论LDH、HMGB-1水平和AChE活性联合检测可评估急性胰腺炎病情进展情况,并预测患者预后。

Objective To investigate values of lactate dehydrogenase(LDH),high mobility group protein-1(HMGB-1)combined with acetylcholinesterase(AChE)activity detection in evaluation of conditions and prognoses of patients with acute pancreatitis.Methods A total of 127 patients with acute pancreatitis admitted between March 2017 and August 2020 were selected as observation group,and 132 healthy subjects who had undergone physical examinations at the same period were selected as control group.Serum levels of LDH and HMGB-1 and the activity of AChE were compared between two groups.Patients'prognoses were recorded,and values of single and combined detection of the three indicators in prediction of prognoses of patients with acute pancreatitis were analyzed.Results Compared with those in control group,serum levels of LDH and HMGB-1 were significantly higher,while the activity of AChE was significantly lower in observation group(P<0.01).Serum levels of LDH and HMGB-1 were increased gradually,while the activity of AChE was decreased gradually with the aggravation of acute pancreatitis(P<0.05).The poor prognosis rate was 14.17%.Compared with those in poor prognosis group,serum levels of LDH and HMGB-1 were significantly lower,while the activity of AChE was significantly higher good prognosis group(P<0.01).Values of sensitivity,specificity and area under curve(AUC)of detection of LDH,HMGB-1 and AChE activity alone were all lower than those of combined detection of the three indexes.Conclusion Combined detection of LDH and HMGB-1 levels and AChE activity can be used to evaluate the progression of acute pancreatitis and predict the prognoses of patients.