重组牛碱性成纤维细胞生长因子联合玻璃酸钠治疗老年白内障术后干眼症患者的效果及对患者泪膜功能、炎症因子的影响

Effect of Recombinant Bovine Basic Fibroblast Grow Factor combined with Sodium Hyaluronate in the treatment of senile patients with dry eye after cataract surgery and its effect on tear film function and inflammatory factors

目的探讨重组牛碱性成纤维细胞生长因子(rb-bFGF)联合玻璃酸钠治疗老年白内障术后干眼症患者的效果及对患者泪膜功能、炎症因子的影响。方法选取2020年11月至2021年10月于新泰市人民医院接受白内障手术的76例(76眼)老年干眼症患者作为研究对象,采用随机摸球法将其分为治疗组(38例,38眼)与对照组(38例,38眼)。对照组采用玻璃酸钠治疗,治疗组采用rb-bFGF联合玻璃酸钠治疗。比较两组患者的临床疗效,比较两组患者治疗前后的泪膜功能和炎症因子水平。结果治疗组患者的治疗总有效率高于对照组,差异有统计学意义(P<0.05);两组患者治疗后的泪膜破裂时间(BUT)长于治疗前,基础泪液分泌试验(SⅠt)高于治疗前,角膜荧光素染色(FL)评分低于治疗前,且治疗组患者治疗后的BUT长于对照组,SⅠt高于对照组,FL评分低于对照组,差异均有统计学意义(P<0.05);两组患者治疗后的白细胞介素-1β(IL-1β)、白细胞介素-8(IL-8)水平低于治疗前,且治疗组患者治疗后的IL-1β、IL-8水平低于对照组,差异有统计学意义(P<0.05)。结论老年白内障术后干眼症患者给予rb-bFGF联合玻璃酸钠治疗,能够提高临床疗效,改善泪膜功能,调节炎症因子水平。

Objective To investigate the effect of Recombinant Bovine Basic Fibroblast Grow Factor(rb-bFGF)combined with Sodium Hyaluronate in the treatment of senile patients with dry eye after cataract surgery and its effect on tear film function and inflammatory factors.Methods A total of 76 elderly patients(76 eyes)with dry eye who were underwent cataract surgery in the People′s Hospital of Xintai City from November 2020 to October 2021 were selected as the research subjects,and they were divided into the treatment group(38 cases,38 eyes)and the control group(38 cases,38 eyes)by random touching-ball method.The control group was treated with Sodium Hyaluronate,the treatment group was treated with rb-bFGF combined with Sodium Hyaluronate.The clinical efficacy of the two groups were compared,and the tear film function and inflammatory factor levels were compared between the two groups before and after treatment.Results The total effective rate in treatment group was higher than that in control group,and the difference was statistically significant(P<0.05).After treatment,the tear film break-up time(BUT)levles of the two groups after treatment were longer than those before treatment,and the SchirmerⅠtest(SⅠt)lengths of the two groups were higher than those before treatment,corneal fluorescein staining(FL)scores of the two groups were lower than those before treatment,and BUT in treatment group after treatment was longer than that in control group,SⅠt in treatment group after treatment was higher than that in control group,FL score in treatment group after treatment was lower than that in control group,the differences were statistically significant(P<0.05).After treatment,the levels of interleukin-1β(IL-1β)and interleukin-8(IL-8)in the two groups were lower than those before treatment,and compared,the levels of IL-1βand IL-8 in the treatment group after treatment were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The treatment of rb-bFGF combined with Sodium Hyaluronate in elderly patients with dry eye after cataract surgery can improve the clinical efficacy,improve tear film function and regulate the level of inflammatory factors.