急性呼吸窘迫综合征肺气血屏障损伤及治疗的研究进展

Role of air-blood barrier injury in acute respiratory distress syndrome and its treatment advances

急性呼吸窘迫综合征是由严重感染、休克、创伤等因素诱发的全身炎症反应,是呼吸系统常见危重症,发生率和死亡率居高不下。肺气血屏障的结构和功能障碍是其发生、发展和转归中的关键机制,其中肺泡上皮细胞和肺血管内皮细胞发挥核心作用。预防和治疗肺气血屏障损伤在疾病的转归中占据重要位置。本文就肺气血屏障的最新研究进行综述,包括急性呼吸窘迫综合征中肺气血屏障结构和功能的变化以及包括中医药在内的针对性治疗,以期为临床合理诊疗提供更多参考。

Acute respiratory distress syndrome(ARDS)is a common respiratory critical disease caused by systemic inflammatory response induced by severe infection,shock,trauma and other factors,with high morbidity and mortality.The structural and functional dysfunction of the air-blood barrier is the key mechanism in its occurrence,development and outcome,and the alveolar epithelial cells and pulmonary vascular endothelial cells play central roles in this progress.Prevention and treatment of the air-blood barrier injury has great effects on the outcome of the disease.In this article,we review the latest research on the air-blood barrier,including the changes of the air-blood barrier structure and function in ARDS and targeted therapies including traditional Chinese medicine,in order to provide more references for clinical rational diagnosis and treatment.