妊娠合并自发性卵巢过度刺激综合征一例

A Case of Spontaneous Ovarian Hyperstimulation Syndrome in Pregnancy

卵巢过度刺激综合征是辅助生殖技术常见的并发症,通常在排卵后2周或2周以上发生。然而自发性卵巢过度刺激综合征极其罕见,一些病例报道表明,自发性卵巢过度刺激综合征的发生与卵泡刺激素受体突变、高人绒毛膜促性腺激素水平、高促甲状腺激素水平、促性腺激素垂体腺瘤等有关。现报告1例双胎妊娠合并自发性卵巢过度刺激综合征的病例,并进一步探讨自发性卵巢过度刺激综合征的可能病因、诊断和治疗原则。

Ovarian hyperstimulation syndrome is a common complication in assisted reproductive technology.It usually occurs after two weeks or more of induced ovulation.However,the spontaneous ovarian hyperstimulation syndrome(sOHSS)is extremely rare.Some clinical cases showed that the etiology of sOHSS was related to the mutations of follicle stimulating hormone receptor gene,the high level of human chorionic gonadotropin(hCG),the high level of thyroid-stimulating hormone(TSH),and gonadotropin pituitary adenoma.In this paper,we report a case of twin pregnancy complicated with sOHSS,and further study the possible etiology,diagnosis and treatment of sOHSS.