中药多糖作为免疫增强剂及其对肠道黏膜影响的研究进展

Research Progress of Chinese Herbal Polysaccharides as Immunopotentiator and Its Effect on Intestinal Mucosa

黏膜是机体免疫的第一道防线,口服、滴鼻、点眼等黏膜免疫途径可有效诱导保护性黏膜免疫反应。但目前绝大多数的黏膜免疫疫苗仍未开发,且缺乏安全有效的免疫增强剂。中药多糖已被证实是一类具有促进黏膜免疫效应的生物活性大分子。本文对近年来不同类型的中药多糖作为免疫增强剂及其对肠道黏膜的影响进行综述,旨在为中药多糖作为黏膜免疫增强剂的开发利用提供新思路。

Mucosa is the frontline of body immune defense.Protective mucosal immune response can be effectively induced by oral administration,nose drop,ocular routes and other mucosal routes.However,most mucosal immune vaccines have not been developed,and there is a lack of safe and effective immunopotentiator.Chinese herbal polysaccharides have been proved as biologically-active macromolecules to promote mucosal immune response.This paper reviews different mucosal immunopotentiator of Chinese herbal polysaccharides and its effect on intestinal mucosa in recent years,in order to provide new ideas for the development and utilization of Chinese herbal polysaccharides as mucosal immune immunopotentiator.