基于SEER数据库的T1M1期结直肠癌临床病理特征及预后分析

Clinical pathological features and prognosis of T1M1 colorectal cancer based on SEER database

目的探讨T1M1期结直肠癌患者的临床病理特征及预后影响因素。方法纳入2010年至2015年美国SEER数据库中的T1M1期结直肠癌数据,应用Kaplan⁃Meier法绘制生存曲线,生存分析采用Log⁃Rank检验,采用Cox比例风险回归模型进行预后的多因素分析。结果共纳入符合要求的T1M1期结直肠癌患者524例,中位随访14个月,结直肠癌特异性死亡443例,中位生存时间12个月。单因素分析结果显示,年龄、性别、肿瘤原发部位、组织分化程度、是否多发转移、手术、区域淋巴结清扫、化疗、CEA与T1M1期结直肠癌患者肿瘤特异性生存密切相关(P<0.05),Cox多因素分析结果显示,年龄、肿瘤原发部位、组织分化程度、手术、化疗、多发转移是影响T1M1期结直肠癌患者预后的独立危险因素。结论年龄≥65岁、右半结肠癌、组织分化程度差、多发转移、未接受手术及化疗的T1M1期结直肠癌患者生存期更短。

Objective To investigate the clinicopathological features and prognosis influencing factors of patients with stage T1M1 colorectal cancer.Methods Patients with stage T1M1 colorectal cancer data in the SEER database from 2010 to 2015 were collected,the survival curve was plotted by Kaplan⁃Meier method,and the survival analysis was tested by Log⁃Rank and the Cox proportional risk regression model was used for prognosis multivariate analysis.Results A total of 524 patients with stage T1M1 colorectal cancer were included,with a median follow⁃up of 14 months,443 patients died of coloretal cancer,and a median survival time of 12 months.Log⁃Rank test results showed that age,sex,primary site of tumor,degree of tissue differentiation,multiple metastasis,surgery,regional lymph node dissection,chemotherapy,CEA were closely related to cancer⁃specific survival in patients with stage T1M1 colorectal cancer(P<0.05),COX multivariate analysis showed that age,primary tumor site,degree of tissue differentiation,surgery,chemotherapy,and multiple metastases were independent risk factors affecting the prognosis of patients with stage T1M1 colorectal cancer.Conclusion Patients with stge T1M1 colorectal cancer age≥65 years,right half colon cancer,poor degree of tissue differentiation,multiple metastases,without surgery and chemotherapy have a shorter survival.