新型冠状病毒感染相关口腔损害

Oral Lesions Associated with 2019-nCoV

新型冠状病毒是2019年底开始流行全球的传染病(COVID-19)-新型冠状病毒病的病原体,对人体呼吸道为主的多个器官造成损伤,口腔损害被认为也是该病常见表现。分析2019年12月至2021年11月期间发表的有关新冠病毒感染与口腔表现文献,总结COVID-19相关口腔损害特征及其可能机制。发现所报告的病例中口腔病变以味觉功能障碍、口干症和溃疡性损害等多见。口腔病损发病机制尚未完全清楚,但口腔上皮细胞广发存在2019-nCoV进入细胞受体ACE2,病毒复制并可能造成组织炎症和破坏是基本的致病机制。

COVID-19 virus is the pathogen of the new type of corona virus disease 2019,a global infectious disease that began to spread at the end of 2019.It has caused damage to multiple organs particularly human respiratory tract.Oral lesions is considered to be a common manifestation of this disease.This article summarized the characteristics and possible mechanisms of COVID-19 related oral damage in novel coronavirus infections and oral manifestations from publications between December 2019 and November 2021.It showed that the oral manifestations of the reported cases were mainly gustatory dysfunction,xerostomia and ulcerative lesions.The mechanism of oral lesions is not yet fully understood,but 2019-nCoV enters the cell receptor ACE2 widely in oral epithelial cells.Virus replication and possible tissue inflammation and destruction could be its possible pathogenic mechanisms.