摘要
针对登革病毒的中和性单克隆抗体因黄病毒属之间的序列同源性而产生交叉反应,如靶向包膜蛋白和非结构蛋白1的抗体等。这些交叉性中和抗体可与黄病毒属的其他病毒结合,发挥对感染动物的保护作用,但也可能在体内引起抗体依赖增强(antibody-dependent enhancement,ADE)效应。本综述就近年来抗登革病毒中和抗体交叉反应性的研究进展进行简要阐述。
Neutralizing monoclonal antibodies against dengue virus cross-react with other flaviviruses due to the sequence homology between them,such as the antibodies targeting envelope protein and non-structural protein 1.Apart from exerting protective effects in infected animals,cross-neutralizing antibodies could also cause antibody-dependent enhancement(ADE)in vivo.This review summarized the progress in cross-reactivity of neutralizing antibodies against dengue virus.
作者
陈楠
柴立辉
肖鹤
Chen Nan;Chai Lihui;Xiao He(Joint National Laboratory for Antibody Drug Engineering,Henan University,Kaifeng 475004,China;Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 100850,China)
出处
《中华微生物学和免疫学杂志》
CAS
CSCD
北大核心
2022年第6期495-499,共5页
Chinese Journal of Microbiology and Immunology
基金
国家科技重大专项(2018ZX10101003-005-009)。
关键词
登革病毒
交叉反应
中和性单克隆抗体
Dengue virus
Cross reaction
Neutralizing monoclonal antibody
