摘要
Chronic heart failure is the end stage of cardiac diseases.With a high prevalence and a high mortality rate worldwide,chronic heart failure is one of the heaviest health-related burdens.In addition to the standard neurohormonal blockade therapy,several medications have been developed for chronic heart failure treatment,but the population-wide improvement in chronic heart failure prognosis over time has been modest,and novel therapies are still needed.
基金
We thank members of the Huang laboratory for advice and support.This work is supported by National Key R&D Program of China(2021YFA1302500)
National Natural Science Foundation of China(81873463 to Z.-P.H.and 82000385 to X.H.)
Guangdong Basic and Applied Basic Research Foundation(2019B151502003 to Z.-P.H.)
the donation for scientific research from the Terry Fox Foundation to Z.-P.H.
