摘要
The global coronavirus disease 2019(COVID-19)pandemic is currently ongoing.It is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).A high proportion of COVID-19 patients exhibit gastrointestinal manifestations such as diarrhea,nausea,or vomiting.Moreover,the respiratory and gastrointestinal tracts are the primary habitats of human microbiota and targets for SARS-CoV-2 infection as they express angiotensin-converting enzyme-2(ACE2)and transmembrane protease serine 2(TMPRSS2)at high levels.There is accumulating evidence that the microbiota are significantly altered in patients with COVID-19 and post-acute COVID-19 syndrome(PACS).
基金
We would like to apologize to those researchers whose related work we were not able to cite in this review.This work was supported by a special program from the Ministry of Science and Technology of China(2021YFA101000)
the Chinese National Natural Science Funds(U20A20393,U20A201376,31925013,3212500161,82041009,31871405,31701234,81902947,82041009,31671457,31571460,and 91753139)
Jiangsu Provincial Distinguished Young Scholars award(BK20180043)
the Key Project of University Natural Science Foundation of Jiangsu Province(19KJA550003)
Zhejiang Provincial Natural Science Foundation of China(LBY21H060001 and LGF19H180007)
Zhejiang Provincial Medical and Health Science and Technology Program(2020RC115)
A project Funded by the Priority Acadamic Program Development of Jiangsu Higher Education Institutions and the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX17_2036).
