摘要
Variants of concern(VOCs)like Delta and Omicron,harbor a high number of mutations,which aid these viruses in escaping a majority of known SARS-CoV-2 neutralizing antibodies(NAbs).In this study,Rhesus macaques immunized with 2-dose inactivated vaccines(Coronavac)were boosted with an additional dose of homologous vaccine or an RBD-subunit vaccine,or a bivalent inactivated vaccine(Beta and Delta)to determine the effectiveness of sequential immunization.The booster vaccination significantly enhanced the duration and levels of neutralizing antibody titers against wild-type.
基金
ACKNOWLEDGEMENTS We thank Sinovac Biotech Ltd for providing the inactivated vaccines as a gift for these prospective studies.This work was supported by the National Research and Development Project of China(Grant Nos.2021YFC0863300,2020YFA0707500,2018YFA0900801)
the CAMS Initiative for Innovative Medicine of China(Grant No.2021-I2M-1-035)
the Strategic Priority Research Program(XDB29010000,XDB37030000),CAS(YSBR-010)
the Special Funds of the National Natural Science Foundation of China(Grant Nos.82061138007 and 92169210)
Xiangxi Wang was supported by the Ten Thousand Talent Program and the NSFS Innovative Research Group(No.81921005).
