摘要
Whether and how innate antiviral response is regulated by humoral metabolism remains enigmatic.We show that viral infection induces progesterone via the hypothalamic-pituitary-adrenal axis in mice.Progesterone induces downstream antiviral genes and promotes innate antiviral response in cells and mice,whereas knockout of the progesterone receptor PGR has opposite effects.Mechanistically,stimulation of PGR by progesterone activates the tyrosine kinase SRC,which phosphorylates the transcriptional factor IRF3 at Y107.
基金
This work was supported by grants from the State Key R&D Program of China(2017YFA0505800 and 2021YFA1302400)
the National Natural Science Foundation of China(31922021,32170713,31830042,and 31771555)
the CAMS Innovation Fund for Medical Sciences(2019-I2M-5-071).
