摘要
Oral squamous cell carcinoma(OSCC)is the most common type of oral malignancy,and metastasis accounts for the poor prognosis of OSCC.Autophagy is considered to facilitate OSCC development by mitigating various cellular stresses;nevertheless,the mechanisms of autophagy in OSCC cell proliferation and metastasis remain unknown.In our study,high-sensitivity label-free quantitative proteomics analysis revealed nuclear protein 1(NUPR1)as the most significantly upregulated protein in formalin-fixed paraffin-embedded tumour samples derived from OSCC patients with or without lymphatic metastasis.
基金
This work was supported by the National Natural Science Foundation of China(81802716,32000552)
the Natural Science Fund of Hunan Province of China(2020JJ5804)
CAMS Innovation Fund for Medical Sciences(2019-I2M-5-037)
Shanghai Clinical Research Center for Oral Diseases(19MC1910600)
Shanghai Municipal Key Clinical Specialty(shslczdzk01601)
Emerging Frontier Technology Joint Research Project(SHDC12018104),the project from Hainan Province Clinical Medical Center.
