摘要
A recent study published in Nature by Li et al.(2021)revealed the underlying mechanism by which Shigella flexneri evades host pyroptosis using a type III secretion system(T3SS)effector,OspC3.OspC3 suppresses the proteolytic activity of caspase-11 or caspase-4(hereafter referred to as‘caspase-11/4’)in a nicotinamide adenine dinucleotide(NAD+)-dependent manner by catalyzing adenosine diphosphate riboxanation(ADP-riboxanation)on arginine 314(Arg314)and Arg310 in caspase-4 and caspase-11,respectively(Figure 1).In addition,S.flexneriΔicsAΔospC3 is a live-attenuated vaccine candidate.
基金
This work was supported by a special program from the Ministry of Science and Technology of China(2016YFA0502500 to L.Z.)
the National Natural Science Foundation of China(U20A201376,31925013,3212500161,82041009,31871405,31701234,81902947,82041009,31671457,31571460,and 91753139)
Jiangsu Provincial Distinguished Young Scholars award(BK20180043)
the Key Project of University Natural Science Foundation of Jiangsu Province(19KJA550003)
a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions and the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX17_2036).
