原发不明颈部转移癌的诊治

Diagnosis and treatment of cervical lymph metastasis carcinoma from unknown primary tumor

原发不明的颈部转移性癌(CCUP)占所有头颈部恶性肿瘤的3%~5%。随着PET-CT、分子病理学、内镜等辅助检查的发展和放疗技术的进步,这类疾病的诊治水平逐渐提高。手术和放射治疗是CCUP最主要的治疗方式。但因CCUP发病率较低、异质性大,目前仍缺少前瞻性临床试验数据,在治疗方面存在很多争议,本文就近年CCUP的诊疗进展做一综述。

Cervical lymph metastasis carcinoma from unknown primary tumor(CCUP)accounts for 3%to 5%of all malignant tumors of head and neck.With the development of PET-CT,molecular pathology,endoscopy and other auxiliary examinations and the advancement of radiotherapy technology,the diagnostic and treatment levels of CCUP have been gradually improved.Surgery and radiotherapy are the most important treatment methods of CCUP.However,due to its low incidence and heterogeneity,prospective clinical trial data are still lacking.Hence,the optimal therapy of CCUP remains highly controversial.In this article,research progresses on the diagnosis and treatment of CCUP in recent years were reviewed.