立体定向放射治疗早期小细胞肺癌研究进展

Research progress on the application of stereotactic body radiation therapy in the treatment of early-stage small cell lung cancer

小细胞肺癌(SCLC)是一种低分化、高侵袭、放化疗敏感的恶性肿瘤。研究发现,接受立体定向放疗(SBRT)的早期SCLC患者,总生存和疾病特异性生存与外科手术及传统同步放化疗接近,且局部控制率高,患者耐受好。SBRT近年来已成为临床I-IIA期SCLC的标准治疗选择之一。鉴于SBRT在SCLC治疗地位的提升,本文将回顾迄今为止的相关临床研究,探讨SBRT在早期SCLC中的应用现状、临床价值及发展趋势。

Small cell lung cancer(SCLC)is a poorly differentiated,rapidly aggressive and highly chemoradio-sensitive malignancy.Recent research finds that stereotactic body radiation therapy(SBRT)is well tolerated in the treatment of early-stage SCLC with excellent locoregional control rates.This paradigm could offer comparable overall survival and cancer-specific survival with surgery or conventional concurrent chemoradiotherapy.Presently,SBRT has become one of the standard treatment options for patients with stage I-IIA SCLC.Due to the enlightened role of SBRT in the treatment of SCLC,this review aims to discuss the clinical research to date in the application status,clinical value and developing tendency of SBRT in the treatment of patients with early-stage SCLC.