多巴胺与特利加压素对顽固性感染性休克的影响

The effect of dopamine and terlipressin on refractory septic shock

目的:探究顽固性感染性休克患者临床治疗中应用多巴胺与特利加压素的临床疗效。方法:选取2019年8月—2020年8月黑龙江佳木斯市中心医院收治顽固性感染性休克患者80例,参照随机数字表法分为对照组和研究组,每组40例。对照组给予液体复苏+多巴胺治疗,研究组在对照组基础联合特利加压素治疗,比较两组临床总疗效、血流动力指标、炎症因子水平、不良反应率。结果:研究组总有效率为95.00%,高于对照组的80.00%,差异有统计学意义(P<0.05);研究组HR、CI、SVRI、MAP指标优于对照组,差异有统计学意义(P<0.05);研究组CRP、TNF-α、PCT水平低于对照组,差异有统计学意义(P<0.05);两组不良反应率比较,差异无统计学意义(P>0.05)。结论:应用多巴胺与特利加压素治疗顽固性感染性休克患者疗效确切,有利于维持患者血流动力学,保护重要器官功能,抑制炎症反应,提高疾病救治成功率,具有应用有效性及安全性。

Objective:To explore the clinical efficacy of dopamine and terlipressin in the clinical treatment of patients with refractory septic shock.Methods:From August 2019 to August 2020,80 patients with intractable septic shock admitted to Jiamusi Central Hospital in Heilongjiang were selected.According to the random number table method,they were divided into control group and study group,with 40 cases in each group.The control group was given liquid resuscitation+dopamine treatment,and the study group was combined with terlipressin treatment in the control group.The total clinical efficacy,hemodynamic indicators,inflammatory factor levels,and adverse reaction rates were compared between the two groups.Results:The total effective rate of the study group was 95.00%,which was higher than 80.00%of the control group.The difference was statistically significant(P<0.05);the HR,CI,SVRI,and MAP indicators of the study group were better than those of the control group,and the difference was statistically significant(P<0.05);The levels of CRP,TNF-αand PCT in the study group were lower than those in the control group,and the difference was statistically significant(P<0.05);The difference in adverse reaction rates between the two groups was not statistically significant(P>0.05).Conclusion:The application of dopamine and terlipressin in the treatment of patients with refractory septic shock has a definite effect,which is beneficial to maintain the patient’s hemodynamics,protect the function of vital organs,inhibit inflammatory reactions,and improve the success rate of disease treatment.It has application effectiveness and safety.sex.