线粒体功能障碍在脊髓损伤中的作用及相关治疗研究进展

Advances of the role of mitochondrial dysfunction in the spinal cord injury and its relevant treatments

目的 综述线粒体功能障碍在脊髓损伤(spinal cord injury,SCI)中的作用及相关治疗研究进展。方法 查阅近年来国内外相关文献,围绕线粒体功能障碍各种机制在SCI中的作用,总结SCI的治疗策略。结果 线粒体功能障碍主要表现在线粒体能量代谢、线粒体氧化应激、线粒体介导的凋亡、线粒体自噬、线粒体通透性转换以及线粒体生物合成等方面异常,在SCI发展中起着重要作用。多种增强线粒体功能的药物治疗SCI有效。结论 线粒体功能障碍可以作为SCI的潜在治疗靶点,为未来SCI治疗药物的开发提供思路和依据。

Objective To review the advances of the role of mitochondrial dysfunction in the spinal cord injury(SCI) and its relevant treatments.Methods Focusing on various mechanisms of mitochondrial dysfunction,recent relevant literature at home and abroad was identified to summarize the therapeutic strategies for SCI.Results Mitochondrial dysfunction is mainly manifested in abnormalities in mitochondrial energy metabolism,mitochondrial oxidative stress,mitochondrial-mediated apoptosis,mitophagy,mitochondrial permeability transition,and mitochondrial biogenesis,playing a vital role in the development of SCI.Drug that enhanced mitochondrial function have been proved beneficial for the treatment of SCI.Conclusion Mitochondrial dysfunction can serve as a potential therapeutic target for SCI,providing ideas and basis for the development of SCI therapeutic candidates in the future.