纳米材料用于关节内靶向递送药物治疗骨关节炎的研究进展

Research progress of nanomaterials for intra-articular targeted drug delivery in treatment of osteoarthritis

目的 对关节内靶向递送纳米材料治疗骨关节炎(osteoarthritis,OA)的研究进展进行综述。方法 广泛查阅国内外关于关节内靶向递送纳米材料治疗OA的相关文献,对其靶向策略进行讨论和总结。结果关节内注射药物主要受限于驻留时间短,不能充分发挥药物的疗效。关节内靶向递送纳米材料不但可以明显提高游离药物在关节内的驻留时间,还可以通过主动或被动靶向策略,实现对特定关节组织的药物递送。结论随着各种新兴组织或细胞特异性药物的不断研发,纳米材料靶向递送药物治疗OA有望实现临床转化。

Objective To review the research progress of intra-articular targeted delivery of nanomaterials in the treatment of osteoarthritis(OA).Methods The domestic and foreign related literature on intra-articular targeted delivery of nanomaterials for the treatment of OA was extensively reviewed,and their targeting strategies were discussed and summarized.Results Rapid drug clearance from the joint remains a critical limitation in drug efficacy.Nanocarriers can not only significantly improve the residence profiles of drugs in the joint,but also achieve targeted delivery of drugs to specific joint tissues through active or passive targeting strategies.Conclusion With the continuous development of various emerging tissue-or cell-specific drugs,the targeted delivery of drugs with nanomaterials promise to realize the clinical translation of these drugs in the treatment of OA.