血清IL-34和GLP-1及vaspin对老年急性心肌梗死患者心血管不良事件评估价值

Evaluation of serum IL-34,GLP-1 and vaspin on cardiovascular adverse events in elderly patients with acute myocardial infarction

目的:探讨血清白介素34(IL-34)、胰高血糖素样肽-1(GLP-1)和脂肪特异性丝氨酸蛋白酶抑制剂(vaspin)对老年急性心肌梗死(AMI)患者心血管不良事件发生的预测价值。方法:选取2017年1月-2019年1月期间我院心血管内科收治的老年AMI患者180例(AMI组)。另选取我院体检健康者100例(对照组)。采用酶联免疫吸附法检测各组血清IL-34、GLP-1、vaspin水平。随访6个月,根据患者有无不良心血管事件发生,分为事件组和非事件组。应用多因素logistic回归分析影响AMI患者心血管不良事件发生的危险因素;绘制受试者工作曲线(ROC),分析血清IL-34、GLP-1、vaspin对AMI患者发生心血管不良事件的预测价值。结果:AMI组血清IL-34、GLP-1、vaspin水平分别与对照组血清IL-34、GLP-1、vaspin水平相比,差异有统计学意义(P<0.05)。事件组患者的血清IL-34、GLP-1高于非事件组患者,血清vaspin水平低于非事件组患者,差异有统计学意义(P<0.05)。ROC曲线示,联合检测血清IL-34、GLP-1、vaspin预测AMI患者发生心血管不良事件的AUC为0.918,敏感度和特异度分别为0.909、0.686。多因素logistic回归分析示:血清IL-34、GLP-1升高,血清vaspin降低是AMI患者发生心血管不良事件的独立危险因素(P<0.05)。结论:老年AMI患者血清IL-34、GLP-1水平升高,血清vaspin水平降低,并与患者不良心血管事件发生有关,早期联合检测血清IL-34、GLP-1、vaspin对评估老年AMI患者心血管不良事件发生的有较高临床价值。

Objective:To investigate the predictive value of serum IL-34,GLP-1 and vaspin on cardiovascular adverse events in elderly patients with acute myocardial infarction(AMI).Methods:A total of 180 elderly AMI patients(AMI group)admitted to our department from January 2017 to January 2019 were selected.Another 100 healthy subjects(control group)were selected in our hospital.Serum levels of interleukin-34(IL-34),glucagon-like peptide-1(GLP-1)and lipid-specific serine protease inhibitors(vaspin)in each group were detected by enzyme-linked immunosorbent assay.After 6 months of follow-up,the patients were divided into event group and non-event group according to the occurrence of adverse cardiovascular events.Multivariate logistic regression was used to analyze the risk factors of cardiovascular adverse events in patients with AMI.Receiver operating curve(ROC)was drawn to analyze the predictive value of serum IL-34,GLP-1 and vaspin for cardiovascular adverse events in patients with AMI.Results:The levels of serum IL-34,GLP-1 and vaspin in the AMI group were significantly different from those in the control group(P<0.05).The serum IL-34 and GLP-1 levels of the patients in the event group were higher than those in the non-event group,and the serum vaspin level was lower than that in the non-event group,and the differences were statistically significant(P<0.05).The ROC curve showed that the combined detection of serum IL-34,GLP-1 and vaspin had an AUC of 0.918 for predicting adverse cardiovascular events in patients with AMI,with a sensitivity and specificity of 0.909 and 0.686,respectively.Multivariate logistic regression analysis showed that the increased serum IL-34 and GLP-1 and the decreased serum vaspin were independent risk factors for cardiovascular adverse events in patients with AMI(P<0.05).Conclusion:The levels of serum IL-34 and GLP-1 are increased and the levels of serum vaspin are decreased in elderly AMI patients,which is related to the occurrence of adverse cardiovascular events in patients.Early combined detection of serum IL-34,GLP-1 and vaspin has high clinical value in evaluating the occurrence of cardiovascular adverse events in elderly AMI patients.