操控冰水:仿生抗冻蛋白研究进展

Research Progress of Bioinspired-Antifreeze Protein Materials

抗冻蛋白是自然界娴熟操控(冰)水的分子识别的典范之一。抗冻蛋白的抗冻活性与其特殊结构有着十分密切的关系。作为目前最高效的生物抗冻剂,抗冻蛋白因其含量低、易变性失活,导致产量过低,亟待开发新的来源。近年来,模拟抗冻蛋白的研究工作吸引了科学家们的广泛关注,抗冻蛋白关键的结构特质:氢键作用、疏水性、冰晶吸附、“结构水”在各类仿生抗结冰材料中相继得以体现,对深入理解抗冻蛋白作用机制起到了重要的推动作用。综述了仿生抗冻蛋白在仿生抗结冰材料领域的研究进展,对基于仿生抗冻蛋白的仿生抗结冰材料的发展做出了展望。

Antifreeze protein is one of the models of molecular recognition that skillfully manipulates(ice)water in nature.The antifreeze activity of antifreeze protein is closely related to its special structure.As the most efficient biological antifreeze at present,antifreeze protein has low yield due to its low content and variable inactivation,so it is urgent to develop new sources.In recent years,the research of simulated antifreeze protein has attracted extensive attention of scientists.The key structural characteristics of antifreeze protein:hydrogen bonding,hydrophobicity,ice crystal adsorption and structural water have been reflected in various bioinspired anti-icing materials,which have played an important role in deeply understanding the functional mechanism of antifreeze protein.In this paper,the research progress of bioinspired antifreeze protein mimics is reviewed,and the development of antifreeze protein and their biomimetic is prospected.