摘要
体外膜肺氧合(ECMO)的抗凝管理面临着巨大挑战,出血或栓塞等凝血系统相关并发症是影响患者死亡率的主要因素之一,如何把控血栓形成与出血并发症之间的动态平衡成为ECMO管理的重中之重。本文对ECMO支持期间的凝血改变,如何选用合适的抗凝药物和抗凝监测手段进行论述,旨在对ECMO患者最佳的抗凝策略进行探讨,更好地服务于ECMO患者。
The anticoagulant management of extracorporeal membrane oxygenation(ECMO)is facing great challenges.Complications related to the coagulation system such as bleeding or embolism are one of the main factors affecting the mortality of patients.How to control the dynamic balance between thrombosis and bleeding complications has become the top priority of ECMO management.This article reviews the coagulation changes during ECMO support,how to choose appropriate anticoagulant drugs and anticoagulation monitoring methods,aiming to explore the best anticoagulation strategy for ECMO patients.
作者
司向
管向东
Si Xiang;Guan Xiangdong(Department of Critical Care Medicine,the First Affiliated Hospital of Sun Yat‑Sen University,the Emergency and Critical Care linical Research Center of Guangdong province,Guangzhou 510080,China)
出处
《中华医学杂志》
CAS
CSCD
北大核心
2022年第25期1864-1869,共6页
National Medical Journal of China
基金
广东省基础与应用基础研究基金(2021A1515111050)
广东省医学科研基金(A2020300)。
关键词
体外膜氧合作用
重症监护
凝血
抗凝
Extracorporeal membrane oxygenation
Intensive care
Coagulation
Anticoagulation
