阿司匹林肠溶片联合硫酸氢氯吡格雷片治疗心血管疾病的临床效果

Clinical effect of aspirin enteric-coated tablets combined with clopidogrel bisulfate tablets in the treatment of cardiovascular diseases

目的探讨阿司匹林肠溶片联合硫酸氢氯吡格雷片治疗心血管疾病的临床效果。方法将2018年2月至2019年11月我院接收的118例心血管疾病患者采用随机数字表法分为对照组(59例,阿司匹林肠溶片)和研究组(59例,阿司匹林肠溶片联合硫酸氢氯吡格雷片)。比较两组的临床效果。结果治疗后,研究组的血小板聚集时间长于对照组,血小板聚集率低于对照组(P<0.05)。治疗后,研究组的心搏出量(SV)及心脏指数(CI)大于对照组(P<0.05)。治疗后,研究组的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)长于对照组,纤维蛋白原(FIB)水平低于对照组(P<0.05)。治疗后,研究组的白细胞介素-6(IL-6)、超敏C-反应蛋白(hs-CRP)及肿瘤坏死因子-α(TNF-α)水平低于对照组(P<0.05)。治疗后,研究组的收缩压、舒张压及心率低于对照组(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。研究组的治疗总有效率高于对照组(P<0.05)。结论阿司匹林肠溶片联合硫酸氢氯吡格雷片治疗心血管疾病可有效改善患者的血小板聚集时间、血小板聚集率、心功能及凝血功能,且不增加不良反应。

Objective To investigate the clinical effect of aspirin enteric-coated tablets combined with clopidogrel bisulfate tablets in the treatment of cardiovascular diseases.Methods A total of 118 patients with cardiovascular diseases received in our hospital from February 2018 to November 2019 were divided into control group(59 cases,aspirin enteric-coated tablets)and study group(59 cases,aspirin enteric-coated tablets combined with clopidogrel bisulfate tablets)by random number table method.The clinical effects of the two groups were compared.Results After treatment,the platelet aggregation time in the study group was longer than that in the control group,and the platelet aggregation rate was lower than that in the control group(P<0.05).After treatment,stroke volume(SV)and cardiac index(CI)in the study group were greater than those in the control group(P<0.05).After treatment,prothrombin time(PT),activated partial thromboplastin time(APTT)and thrombin time(TT)in the study group were longer than those in the control group,and fibrinogen(FIB)level was lower than that in the control group(P<0.05).After treatment,the levels of interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP)and tumor necrosis factor-α(TNF-α)in the study group were lower than those in the control group(P<0.05).After treatment,the systolic blood pressure,diastolic blood pressure and heart rate in the study group were lower than those in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).The total effective rate of treatment in the study group was higher than that in the control group(P<0.05).Conclusion Aspirin enteric-coated tablets combined with clopidogrel bisulfate tablets in the treatment of cardiovascular diseases can effectively improve the platelet aggregation time,platelet aggregation rate,cardiac function and coagulation function,without increasing adverse reactions.