银黄颗粒联合头孢唑林钠治疗老年急性上呼吸道感染的效果及对患者炎症反应的影响

Effect of Yinhuang granule combined with cefazolin sodium in the treatment of elderly patients with acute upper respiratory tract infection and its influence on the inflammatory response

目的探究银黄颗粒联合头孢唑林钠治疗老年急性上呼吸道感染的效果及对患者炎症反应的影响。方法选择我院2018年3月至2020年6月收治的96例老年急性上呼吸道感染患者为研究对象,采用随机数字表法将其分为对照组(n=48,头孢唑林钠)和观察组(n=48,银黄颗粒联合头孢唑林钠)。比较两组的治疗效果。结果治疗后,观察组的血浆白细胞计数及血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、降钙素原(PCT)水平低于对照组(P<0.05)。观察组的退热时间、止咳时间、咽痛缓解时间、咽部充血消失时间均显著短于对照组(P<0.05)。观察组的治疗总有效率明显高于对照组(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论银黄颗粒联合头孢唑林钠治疗老年急性上呼吸道感染的效果显著,可减轻临床症状,显著抑制呼吸道炎症反应,且安全性高。

Objective To explore the effect of Yinhuang granule combined with cefazolin sodium in the treatment of elderly patients with acute upper respiratory tract infection and its influence on the inflammatory response.Methods Ninety-six elderly patients with acute upper respiratory tract infection treated in our hospital from March 2018 to June 2020 were selected as the research objects and divided into control group(n=48,cefazolin sodium)and observation group(n=48,Yinhuang granule combined with cefazolin sodium)according to random number table method.The therapeutic effects of the two groups were compared.Results After treatment,the plasma leukocyte count and levels of serum tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and procalcitonin(PCT)in the observation group were lower than those in the control group(P<0.05).The antipyretic time,relieving cough time,relieving time of pharyngeal pain and disappearance time of pharyngeal congestion in the observation group were significantly shorter than those in the control group(P<0.05).The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Yinhuang granule combined with cefazolin sodium is effective in the treatment of acute upper respiratory tract infection in the elderly,which can reduce clinical symptoms,and significantly inhibit respiratory inflammatory response,with high safety.